Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.38 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2849627 | 0.82 | MPO (0.39) | CYP3A4CYP2C19KDM4EMPOALDH1A1 | |
| SCHEMBL282988 | 0.78 | ALDH1A1 (0.44) | CYP2D6CYP1A2CYP3A4CYP2C19KDM4E | |
| Isonicotinic Acid SCHEMBL28953803 | 0.78 | NAPRT (0.49) | CYP2D6CYP1A2CYP3A4CYP2C19KDM4E | |
| SCHEMBL16791675 | 0.77 | CYP2D6 (0.42) | CYP2D6CYP1A2CYP3A4CYP2C19KDM4E | |
| SCHEMBL8272442 | 0.76 | ALDH1A1 (0.43) | CYP2D6CYP1A2CYP3A4CYP2C19KDM4E | |
| SCHEMBL3557897 | 0.75 | F2 (0.52) | CYP2D6CYP1A2CYP3A4CYP2C19KDM4E | |
| SCHEMBL13108737 | 0.75 | WDR5 (0.44) | CYP3A4KDM4EMPOALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL27786828 | 0.74 | ALDH1A1 (0.41) | CYP2D6CYP1A2CYP3A4CYP2C19KDM4E | |
| SCHEMBL4921939 | 0.74 | F7 (0.52) | CYP1A2CYP3A4ALDH1A1GAAPLOD2 | |
| Hydrochloric Acid SCHEMBL3557093 | 0.73 | BLM (0.54) | CYP2D6CYP1A2CYP3A4CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023049438-A1 | GRK2 INHIBITORS AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |
| US-8207147-B2 | Heterocyclic derivatives as GPCR receptor agonists | PROSIDION LIMITED (GB) | 2012-06-26 | — | — | US | disclosed |
| US-20090281060-A1 | HETEROCYCLIC DERIVATIVES AS GPCR RECEPTOR AGONISTS | PROSIDION LIMITED (GB) | 2009-11-12 | — | — | US | disclosed |
| US-20080096894-A1 | Anti-Bacterial Compounds | ASTON UNIVERSITY (GB) | 2008-04-24 | — | — | US | disclosed |
| EP-1845779-A1 | ANTI-BACTERIAL COMPOUNDS | Aston University (GB) | 2007-10-24 | — | — | EP | disclosed |
| US-20070129371-A1 | Novel ethylenediamine derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-06-07 | — | — | US | disclosed |
| WO-2006111716-A1 | HETEROARYL DERIVATIVES HAVING ANTI-MYCOBACTERIAL ACTIVITY | ASTON UNIVERSITY (GB) | 2006-10-26 | — | — | WO | disclosed |
| WO-2006075159-A1 | ANTI-BACTERIAL COMPOUNDS | ASTON UNIVERSITY (GB) | 2006-07-20 | — | — | WO | disclosed |
| EP-1577302-A1 | NOVEL ETHYLENEDIAMINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2005-09-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129371-A1 | Novel ethylenediamine derivatives | C1R, C9, C1S | CYP2D6 1232/4885CYP1A2 3302/4885CYP3A4 1865/4885 |
| US-20090281060-A1 | HETEROCYCLIC DERIVATIVES AS GPCR RECEPTOR AGONISTS | GPR119, GCGR, GLP1R | CYP2D6 1397/4885CYP1A2 873/4885CYP3A4 1365/4885 |
| US-20080096894-A1 | Anti-Bacterial Compounds | MRPL21, PGLS, FOSB | CYP2D6 2324/4885CYP1A2 3458/4885CYP3A4 3723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.