Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28377875 | 0.92 | TP53 (0.61) | ALDH1A1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL28377910 | 0.91 | — | — | |
| SCHEMBL28373339 | 0.91 | LMNA (0.61) | ALDH1A1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL28374054 | 0.91 | KDM4E (0.55) | ALDH1A1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL28379969 | 0.88 | KDM4E (0.60) | ALDH1A1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL28375732 | 0.87 | FAAH (0.58) | ALDH1A1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL28885931 | 0.87 | SIGMAR1 (0.68) | ALDH1A1KDM4EKMT2AMEN1L3MBTL1 | |
| SCHEMBL28377450 | 0.87 | ALDH1A1 (0.64) | ALDH1A1KDM4ESMN1; SMN2LMNATSHR | |
| SCHEMBL28374694 | 0.86 | ALDH1A1 (0.64) | ALDH1A1KDM4ESMN1; SMN2LMNAMAPK1 | |
| SCHEMBL1921739 | 0.86 | L3MBTL1 (0.43) | ALDH1A1KDM4EKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110615774-B | Benzyl piperazine compound with anti-inflammatory activity, preparation method and medical application | 安徽中医药大学 | 2022-11-11 | — | — | CN | disclosed |
| CN-110615774-A | Benzyl piperazine compound with anti-inflammatory activity, preparation method and medical application | 安徽中医药大学 | 2019-12-27 | — | — | CN | disclosed |
| US-9150561-B2 | Thiazole derivatives and use thereof | MERCK SERONO S.A. (CH) | 2015-10-06 | — | — | US | disclosed |
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | MERCK SERONO S.A. (CH) | 2014-08-14 | — | — | US | disclosed |
| US-8802861-B2 | Thiazole derivatives and use thereof | MERCK SERONO SA (CH) | 2014-08-12 | — | — | US | disclosed |
| US-20090029998-A1 | Thiazole Derivatives and Use Thereof | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2009-01-29 | — | — | US | disclosed |
| EP-1709019-B1 | THIAZOLE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS (AN) | 2007-08-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | PF4, TEC, PDGFRB | ALDH1A1 234/4885KDM4E 4820/4885KMT2A 4760/4885 |
| US-20090029998-A1 | Thiazole Derivatives and Use Thereof | PDGFRB, PDGFRA, TEC | ALDH1A1 174/4885KDM4E 4801/4885KMT2A 4737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.