SCHEMBL451612

SCHEMBL451612

c1ccc(C2CNCCN2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC18A3 Q16572 1/20 0.43
SIGMAR1 Q99720 1/20 0.43
PRCP P42785 2/20 0.42
TAAR1 Q96RJ0 1/20 0.41
KDM1A O60341 2/20 0.39
MAOB P27338 2/20 0.39
MAOA P21397 1/20 0.39
GBA1 P04062 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
LTA4H P09960 1/20 0.38
BMPR1B O00238 1/20 0.37
PDGFRB P09619 1/20 0.37
KDR P35968 1/20 0.37
ACVR1B P36896 1/20 0.37
TGFBR1 P36897 1/20 0.37
TGFBR2 P37173 1/20 0.37
ADCY6 O43306 1/20 0.37
ADCY3 O60266 1/20 0.37
ADCY9 O60503 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1638075 1.00 SLC18A3 (0.43) SLC18A3SIGMAR1PRCPTAAR1KDM1A
SCHEMBL1639225 1.00 SLC18A3 (0.43) SLC18A3SIGMAR1PRCPTAAR1KDM1A
SCHEMBL8193202 0.98 SLC18A3 (0.47) SLC18A3SIGMAR1PRCPTAAR1KDM1A
Piperidine SCHEMBL27283393 0.91 SLC18A3 (0.41) SLC18A3SIGMAR1PRCPTAAR1KDM1A
Pyridine SCHEMBL28302986 0.89 CHRNB2 (0.44) SLC18A3SIGMAR1PRCPTAAR1MEN1
SCHEMBL8220636 0.88 CTSL (0.46) TAAR1KDM1AMAOBMEN1KMT2A
SCHEMBL28677309 0.88 SLC18A3 (0.42) SLC18A3SIGMAR1PRCPTAAR1KDM1A
SCHEMBL9829845 0.88 KDM1A (0.41) SLC18A3SIGMAR1PRCPTAAR1KDM1A
Hydrochloric Acid SCHEMBL28196337 0.88 CHRNB2 (0.50) SLC18A3SIGMAR1KDM1AMAOBMEN1
SCHEMBL28841712 0.84 LTA4H (0.55) MAOBLTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 499 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120117949-A Method for directly preparing tertiary amine compound from aromatic aldehyde, ketone and secondary amine 湖南大学 2025-06-10 CN claimed
CN-113387830-A Bio-based flame-retardant anti-aging dual-functional integrated auxiliary agent and preparation method thereof 四川大学 2021-09-14 CN claimed
CN-109810047-A (R) synthetic method of the chiral intermediate of -3- Phenylpiperidine or/and (S) -3- Phenylpiperidine and Ni Lapani 上海博邦医药科技有限公司 2019-05-28 CN claimed
CN-105669970-B Polyamide-based expandable flame retardant carbon forming agent and its preparation method and application of the main chain containing piperazine structure 四川大学 2018-11-02 CN claimed
CN-106084286-B A kind of halogen-free expansion type flame-proof carbon forming agent compound and preparation method thereof 浙江旭森非卤消烟阻燃剂有限公司 2018-10-30 CN claimed
CN-106084371-B A kind of fire-retardant carbon forming agent compound of halogen-free polyolefin and preparation method thereof 浙江旭森非卤消烟阻燃剂有限公司 2018-10-30 CN claimed
CN-107266447-A A kind of preparation method of Mirtazapine 江西永通科技股份有限公司 2017-10-20 CN claimed
CN-103616806-B Cleaning fluid for photosensitive membrane 马佳 2017-02-08 CN claimed
CN-106366670-A Macromolecule flame retardant containing P, SI, S and N elements and preparation method thereof 浙江旭森非卤消烟阻燃剂有限公司 2017-02-01 CN claimed
CN-103605269-B Light-sensitive surface cleanout fluid for semiconductor manufacturing 马佳 2016-11-23 CN claimed
CN-101042543-A Chemical cleaning composition for cleaning resist remover DONGJIN SEMICHEM CO LTD (KR) 2007-09-26 CN claimed
CN-1939918-A Production of midanping DEZHONGWANQUAN MEDICAL SCIENCE (CN) 2007-04-04 CN claimed
CN-1924710-A Optical resist clearing agent composition for wiping improved optical resist of semiconductor device DONGJIN SEMICHEM CO LTD (KR) 2007-03-07 CN claimed
US-6906074-B2 2-phenylpiperazine derivatives NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) 2005-06-14 US claimed
US-20030166616-A1 Novel 2-phenylpiperazine derivatives NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) 2003-09-04 US claimed
EP-1338592-A1 Novel 2-phenylpiperazine derivatives NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) 2003-08-27 EP claimed
EP-0211746-B1 PHENYL-PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THERAPEUTICAL USE LABORATOIRE L. LAFON Société anonyme dite: (FR) 1990-05-23 EP claimed
CN-1003236-B Preparation method of 6, 7-disubstituted-1-cyclopropyl-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid 拜尔公司 1989-02-08 CN claimed
US-4705788-A Novel antibacterial 7-amino-1(substituted cyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids BAYER AKTIENGESELLSCHAFT (DE) 1987-11-10 US claimed
EP-0211746-A1 Phenyl-piperazine derivatives, process for their preparation and therapeutical use LABORATOIRE L. LAFON Société anonyme dite: (FR) 1987-02-25 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030166616-A1 Novel 2-phenylpiperazine derivatives VIPR2, BDKRB2, TRPC5 SLC18A3 135/4885SIGMAR1 1005/4885PRCP 330/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.