Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 6/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.41 |
| ▸ | PDE5A | O76074 | 3/20 | 0.41 |
| ▸ | PDE1A | P54750 | 3/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4521820 | 0.92 | PDE4A (0.40) | SMN1; SMN2HKDC1TSHRPDE4APDE4B | |
| SCHEMBL4520110 | 0.92 | SMN1; SMN2 (0.40) | SMN1; SMN2HKDC1TSHRATML3MBTL1 | |
| SCHEMBL4531050 | 0.90 | SMN1; SMN2 (0.42) | SMN1; SMN2HKDC1TSHRPDE4APDE4B | |
| SCHEMBL4529801 | 0.90 | SMN1; SMN2 (0.39) | SMN1; SMN2HKDC1TSHRATML3MBTL1 | |
| SCHEMBL4531589 | 0.90 | HKDC1 (0.39) | SMN1; SMN2HKDC1TSHRPDE4APDE4B | |
| SCHEMBL4526238 | 0.89 | YTHDC1 (0.43) | SMN1; SMN2HKDC1TSHRPDE4APDE4B | |
| SCHEMBL4531196 | 0.88 | HKDC1 (0.39) | SMN1; SMN2HKDC1TSHRPDE4APDE4B | |
| SCHEMBL4521974 | 0.88 | SMN1; SMN2 (0.39) | SMN1; SMN2HKDC1TSHRATML3MBTL1 | |
| SCHEMBL4522632 | 0.86 | HKDC1 (0.39) | SMN1; SMN2HKDC1TSHRPDE4APDE4B | |
| SCHEMBL4507591 | 0.86 | MAT2A (0.43) | SMN1; SMN2HKDC1TSHRCDK1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298856-A1 | 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1) | BROWN REBECCA ELIZABETH | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298856-A1 | 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1) | TRPV1, TRPV2, TRPV4 | SMN1; SMN2 3506/4885HKDC1 2603/4885TSHR 915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.