Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 6/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4515108 | 0.92 | CNR1 (0.38) | CDK1ADORA2AADORA1PDE4APDE4B | |
| SCHEMBL4522496 | 0.92 | CDK1 (0.39) | HKDC1SMN1; SMN2CDK1ADORA2APDE4A | |
| SCHEMBL4522199 | 0.91 | CDK1 (0.38) | HKDC1SMN1; SMN2CDK1PDE4APDE4B | |
| SCHEMBL4520110 | 0.89 | SMN1; SMN2 (0.40) | HKDC1SMN1; SMN2CDK1ADORA2AADORA1 | |
| SCHEMBL4518958 | 0.88 | SMN1; SMN2 (0.43) | HKDC1SMN1; SMN2CDK1PDE4APDE4B | |
| SCHEMBL4530785 | 0.85 | MAT2A (0.38) | CDK1ADORA2APDE4APDE4BPDE4C | |
| SCHEMBL4531589 | 0.84 | HKDC1 (0.39) | HKDC1SMN1; SMN2CDK1PDE4APDE4B | |
| SCHEMBL4521974 | 0.84 | SMN1; SMN2 (0.39) | HKDC1SMN1; SMN2CDK1PDE4APDE4B | |
| SCHEMBL4529801 | 0.84 | SMN1; SMN2 (0.39) | HKDC1SMN1; SMN2CDK1PDE4APDE4B | |
| SCHEMBL4520799 | 0.84 | CTSV (0.39) | HKDC1SMN1; SMN2CDK1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298856-A1 | 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1) | BROWN REBECCA ELIZABETH | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298856-A1 | 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1) | TRPV1, TRPV2, TRPV4 | HKDC1 2603/4885SMN1; SMN2 3506/4885CDK1 1523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.