Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 7/20 | 0.41 |
| ▸ | THRA | P10827 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727500 | 0.87 | KMT2A (0.53) | SMN1; SMN2ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL5344673 | 0.86 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4521290 | 0.86 | MAPT (0.56) | SMN1; SMN2ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL4524284 | 0.82 | L3MBTL1 (0.37) | SMN1; SMN2THRBTHRAMEN1KMT2A | |
| SCHEMBL16107476 | 0.81 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL31516973 | 0.77 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1THRBTHRAMEN1 | |
| SCHEMBL4529675 | 0.75 | TAAR1 (0.49) | SMN1; SMN2ALDH1A1MEN1KMT2AOPRM1 | |
| SCHEMBL16107394 | 0.75 | PKM (0.44) | SMN1; SMN2ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL22454599 | 0.74 | TDP1 (0.50) | SMN1; SMN2ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL3840012 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221653-A1 | 7-(2-amino-1-hydroxy-ethyl)-4-hydroxybenzothiazol-2(3H)-one-derivatives as beta2 adrenoreceptor agonists | ASTRAZENECA AB (SE) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221653-A1 | 7-(2-amino-1-hydroxy-ethyl)-4-hydroxybenzothiazol-2(3H)-one-derivatives as beta2 adrenoreceptor agonists | ADRB2, ADRB1, ADRA2C | SMN1; SMN2 3368/4885ALDH1A1 243/4885THRB 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.