Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4525031 | 0.92 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2RENLMNAKMT2A | |
| SCHEMBL4528645 | 0.86 | GAA (0.43) | ALDH1A1SMN1; SMN2LMNAKMT2AMAPT | |
| SCHEMBL4528051 | 0.82 | SLC6A4 (0.43) | SLC6A2SLC6A4RENSLC6A3HTR2A | |
| SCHEMBL4535829 | 0.80 | CYP1A2 (0.45) | ALDH1A1SMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL27270132 | 0.79 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2LMNAKMT2AMAPT | |
| SCHEMBL3161090 | 0.76 | MEN1 (0.46) | ALDH1A1SMN1; SMN2LMNAKMT2AMAPT | |
| SCHEMBL7426435 | 0.76 | KMT2A (0.40) | ALDH1A1SMN1; SMN2RENLMNAKMT2A | |
| SCHEMBL7423995 | 0.76 | POLB (0.44) | LMNAPOLB | |
| SCHEMBL4526670 | 0.76 | REN (0.43) | SLC6A2SLC6A4RENSLC6A3KMT2A | |
| SCHEMBL663586 | 0.76 | REN (0.43) | ALDH1A1SLC6A2SLC6A4RENSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | PLE PATRICK | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | AQP3, AQP1, F12 | ALDH1A1 2449/4885SMN1; SMN2 4036/4885SLC6A2 533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.