Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.65 |
| ▸ | HTR2B | P41595 | 1/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5963374 | 1.00 | KMT2A (0.72) | KMT2AADRB2ADRB1HTR1AADRA2C | |
| SCHEMBL7317527 | 0.86 | KMT2A (0.67) | KMT2AADRB2ADRB1HTR1AADRA2C | |
| SCHEMBL11097621 | 0.86 | KMT2A (0.70) | KMT2AADRB2ADRB1HTR1AADRA2C | |
| Hydrochloric Acid SCHEMBL11094534 | 0.85 | KMT2A (0.71) | KMT2AADRB2ADRB1HTR1AADRA2C | |
| SCHEMBL7320022 | 0.85 | ADRB2 (0.78) | KMT2AADRB2ADRB1HTR1AADRA2C | |
| SCHEMBL8835982 | 0.85 | KMT2A (0.78) | KMT2AADRB2ADRB1HTR1AADRA2C | |
| SCHEMBL11884643 | 0.85 | ADRB2 (0.80) | KMT2AADRB2ADRB1HTR1AADRA2C | |
| SCHEMBL14155281 | 0.84 | KMT2A (0.62) | KMT2AADRB2ADRB1HTR1AADRA2C | |
| SCHEMBL10554140 | 0.83 | KMT2A (0.75) | KMT2AADRB2ADRB1HTR1AADRA2C | |
| SCHEMBL11259043 | 0.83 | KMT2A (0.75) | KMT2AADRB2ADRB1HTR1AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129379-B2 | 3-amino-propoxphenyl derivatives (l) | WILLIAM JOHN LOUIS, AUSTIN AND REPATRIATION MEDICAL CENTRE (AU) | 2006-10-31 | — | — | US | claimed |
| EP-0937030-B1 | 3-AMINO-PROPOXYPHENYL DERIVATIVES (I) | LOUIS WILLIAM JOHN (AU) | 2004-03-31 | — | — | EP | claimed |
| US-20030216477-A1 | 3-amino-propoxphenyl derivatives (I) | THE UNIVERSITY OF MELBOURNE | 2003-11-20 | — | — | US | claimed |
| US-6627662-B2 | Potent, beta 1-specific beta blockers with a short duration of action in the systemic circulation, wherein R is 3',4'-dimethoxyphenyl. R1 is hydrogen, and R2 is selected from methyl, ethyl, propyl, isobutyl and isopropyl; or R is | WILLIAM JOHN LOUIS, AUSTIN AND REPATRIATION MEDICAL CENTRE (AU) | 2003-09-30 | — | — | US | claimed |
| US-20150051270-A1 | Novel Cyclic Phenoxy Compounds and Improved Treatments for Cardiac and Cardiovascular Disease | UNIV NOTTINGHAM (GB) | 2015-02-19 | — | — | US | disclosed |
| US-20130261178-A1 | PHENOXYPROPANOL DERIVATIVES AND THEIR USE IN TREATING CARDIAC AND CARDIOVASCULAR DISEASES | MISTRY SHAILESH (GB) | 2013-10-03 | — | — | US | disclosed |
| JP-2009040769-A | 3-AMINO-PROPOXYPHENYL DERIVATIVE (I) | LOUIS WILLIAM JOHN | 2009-02-26 | — | — | JP | disclosed |
| US-7129379-B2 | 3-amino-propoxphenyl derivatives (l) | WILLIAM JOHN LOUIS, AUSTIN AND REPATRIATION MEDICAL CENTRE (AU) | 2006-10-31 | — | — | US | disclosed |
| EP-0937030-B1 | 3-AMINO-PROPOXYPHENYL DERIVATIVES (I) | LOUIS WILLIAM JOHN (AU) | 2004-03-31 | — | — | EP | disclosed |
| US-20030216477-A1 | 3-amino-propoxphenyl derivatives (I) | THE UNIVERSITY OF MELBOURNE | 2003-11-20 | — | — | US | disclosed |
| US-6627662-B2 | Potent, beta 1-specific beta blockers with a short duration of action in the systemic circulation, wherein R is 3',4'-dimethoxyphenyl. R1 is hydrogen, and R2 is selected from methyl, ethyl, propyl, isobutyl and isopropyl; or R is | WILLIAM JOHN LOUIS, AUSTIN AND REPATRIATION MEDICAL CENTRE (AU) | 2003-09-30 | — | — | US | disclosed |
| US-20030100616-A1 | 3-AMINO-PROPOXYPHENYL DERIVATIVES (I) | LOUIS, WILLIAM JOHN, AUSTIN AND REPATRIATION MEDICAL CENTRE (AU) | 2003-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130261178-A1 | PHENOXYPROPANOL DERIVATIVES AND THEIR USE IN TREATING CARDIAC AND CARDIOVASCULAR DISEASES | NR3C2, NPR3, ADRB3 | KMT2A 4656/4885ADRB2 18/4885ADRB1 14/4885 |
| US-20030216477-A1 | 3-amino-propoxphenyl derivatives (I) | ADRB1, ADRB3, ADRB2 | KMT2A 3287/4885ADRB2 3/4885ADRB1 1/4885 |
| US-20030100616-A1 | 3-AMINO-PROPOXYPHENYL DERIVATIVES (I) | ADRB1, ADRB3, ADRB2 | KMT2A 3068/4885ADRB2 3/4885ADRB1 1/4885 |
| US-20150051270-A1 | Novel Cyclic Phenoxy Compounds and Improved Treatments for Cardiac and Cardiovascular Disease | OXER1, NPR1, RER1 | KMT2A 2641/4885ADRB2 283/4885ADRB1 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.