SCHEMBL453430

SCHEMBL453430

CC(C)(C)[Si](OCCN)(c1ccccc1)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.44
KIF11 P52732 1/20 0.40
KDM4E B2RXH2 2/20 0.39
TAAR1 Q96RJ0 2/20 0.39
SMYD2 Q9NRG4 3/20 0.39
CYP3A4 P08684 2/20 0.39
HTT P42858 1/20 0.39
MAPK1 P28482 2/20 0.36
HPGD P15428 2/20 0.36
MEN1 O00255 1/20 0.36
TRPM2 O94759 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CYP1A2 P05177 1/20 0.36
THRB P10828 1/20 0.36
ALOX15 P16050 1/20 0.36
TSHR P16473 1/20 0.36
ALOX12 P18054 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
TP53 P04637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5727505 0.95 SMN1; SMN2 (0.41) SMN1; SMN2KIF11KDM4ETAAR1SMYD2
SCHEMBL30426193 0.90 SMN1; SMN2 (0.40) SMN1; SMN2KIF11KDM4ETAAR1SMYD2
SCHEMBL15679439 0.90 SMN1; SMN2 (0.40) SMN1; SMN2KIF11KDM4ETAAR1SMYD2
SCHEMBL29026181 0.90 SMN1; SMN2 (0.40) SMN1; SMN2KIF11KDM4ETAAR1SMYD2
SCHEMBL927307 0.90 SMN1; SMN2 (0.40) SMN1; SMN2KIF11KDM4ETAAR1SMYD2
SCHEMBL2818126 0.89 SMN1; SMN2 (0.38) SMN1; SMN2KIF11TAAR1SMYD2CYP3A4
SCHEMBL3933299 0.88 SMN1; SMN2 (0.37) SMN1; SMN2SMYD2CYP3A4HTT
SCHEMBL31400145 0.86 SMN1; SMN2 (0.37) SMN1; SMN2SMYD2CYP3A4HTT
SCHEMBL15645028 0.86 SMN1; SMN2 (0.37) SMN1; SMN2SMYD2CYP3A4HTT
SCHEMBL3939837 0.86 SMN1; SMN2 (0.37) SMN1; SMN2SMYD2CYP3A4HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 135 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260125383-A1 INDAZOLE INHIBITORS OF CYCLIC GMP-AMP SYNTHASE AND USES THEREOF VENTUS THERAPEUTICS U.S., INC. (US) 2026-05-07 US disclosed
WO-2025098391-A9 SELECTIVE DRUG RELEASE FROM CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS NONA BIOSCIENCES (SUZHOU) CO., LTD. (CN) 2026-04-30 WO disclosed
US-20260115139-A1 Amino Acid-Containing Ionizable Lipids for the Delivery of Therapeutic Agents NANOVATION THERAPEUTICS INC. (CA) 2026-04-30 US disclosed
EP-4694981-A1 HETEROCYCLIC COMPOUNDS AS DUAL INHIBITORS OF PD-L1 AND ADENOSINE RECEPTORS Aurigene Oncology Limited (IN) 2026-02-18 EP disclosed
WO-2025202022-A9 ANTICANCER MACROCYCLIC QUINAZOLINE-BASED INHIBITORS OF THE INERACTION BETWEEN RAS AND SOS1 BAYER AKTIENGESELLSCHAFT (DE) 2025-12-26 WO disclosed
WO-2025202022-A1 ANTICANCER MACROCYCLIC QUINAZOLINE-BASED INHIBITORS OF THE INERACTION BETWEEN RAS AND SOS1 BAYER AKTIENGESELLSCHAFT (DE) 2025-10-02 WO disclosed
EP-4594293-A1 AMINO ACID-CONTAINING IONIZABLE LIPIDS FOR THE DELIVERY OF THERAPEUTIC AGENTS Nanovation Therapeutics Inc. (CA) 2025-08-06 EP disclosed
US-20250235547-A1 ANTIBODY-DRUG CONJUGATE UBE CORPORATION (JP) 2025-07-24 US disclosed
WO-2025151594-A1 FUSED AZINES AS RAS INHIBITORS AND METHODS OF USE THEREOF KESTREL THERAPEUTICS INC. (US) 2025-07-17 WO disclosed
US-20250170267-A1 ANTIBODY-DRUG CONJUGATE PRECURSOR AND INTERMEDIATE FOR SYNTHESIS THEREOF UBE CORPORATION (JP) 2025-05-29 US disclosed
US-6355257-B1 Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors CORIXA CORPORATION 2002-03-12 US disclosed
US-6303347-B1 VACCINES CORIXA CORPORATION 2001-10-16 US disclosed
EP-1140895-A2 THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-10-10 EP disclosed
WO-2001034617-A2 AMINOALKYL GLUCOSAMINIDE PHOSPHATE COMPOUNDS AND THEIR USE AS ADJUVANTS AND IMMUNOEFFECTORS CORIXA CORPORATION (US) 2001-05-17 WO disclosed
US-6113918-A IMMUNOLOGY RIBI IMMUNOCHEM RESEARCH, INC. (US) 2000-09-05 US disclosed
WO-2000040576-A2 THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-07-13 WO disclosed
EP-0983286-A1 AMINOALKYL GLUCOSAMINE PHOSPHATE COMPOUNDS AND THEIR USE AS ADJUVANTS AND IMMUNOEFFECTORS CORIXA CORPORATION (US) 2000-03-08 EP disclosed
WO-1998050399-A1 AMINOALKYL GLUCOSAMINE PHOSPHATE COMPOUNDS AND THEIR USE AS ADJUVANTS AND IMMUNOEFFECTORS CORIXA CORPORATION (US) 1998-11-12 WO disclosed
EP-0104888-B1 PROCESS FOR PREPARING 2-HYDROXY-2-PHENYLETHYLAMINES ELI LILLY AND COMPANY (US) 1986-10-15 EP disclosed
EP-0104888-A1 Process for preparing 2-hydroxy-2-phenylethylamines ELI LILLY AND COMPANY (US) 1984-04-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260115139-A1 Amino Acid-Containing Ionizable Lipids for the Delivery of Therapeutic Agents SLC43A1, SLC7A1, SLC7A5 SMN1; SMN2 667/4885KIF11 3050/4885KDM4E 4032/4885
US-20260125383-A1 INDAZOLE INHIBITORS OF CYCLIC GMP-AMP SYNTHASE AND USES THEREOF CGAS, PRKG1, GMPS SMN1; SMN2 3863/4885KIF11 4672/4885KDM4E 4755/4885
US-20250235547-A1 ANTIBODY-DRUG CONJUGATE LDHB, LDHA, DLST SMN1; SMN2 3309/4885KIF11 616/4885KDM4E 2501/4885
US-20250170267-A1 ANTIBODY-DRUG CONJUGATE PRECURSOR AND INTERMEDIATE FOR SYNTHESIS THEREOF DLST, LANCL1, DDOST SMN1; SMN2 2577/4885KIF11 1209/4885KDM4E 1736/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.