Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.44 |
| ▸ | CHUK | O15111 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535022 | 0.84 | KDM1A (0.53) | ADRB3KMT2AMCL1MEN1LMNA | |
| SCHEMBL30841998 | 0.79 | ADRA2A (0.62) | ADRB3ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL4303130 | 0.76 | NPC1 (0.43) | ADRB3HPGDNPC1KDM4EALDH1A1 | |
| SCHEMBL28174998 | 0.75 | HPGD (0.51) | LMNAGAAHPGDNPC1NFKB1 | |
| SCHEMBL3657859 | 0.75 | ADRB3 (0.42) | ADRB3ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL3633978 | 0.75 | TRPV1 (0.51) | — | |
| SCHEMBL6707802 | 0.74 | ADRA2A (0.43) | ADRB3LMNAHPGDNPC1KDM4E | |
| SCHEMBL15771314 | 0.73 | CKS1B (0.47) | KMT2AMCL1LMNAL3MBTL1CKS1B | |
| SCHEMBL1815685 | 0.72 | CYP1A2 (0.50) | KMT2ALMNAGAAHPGDNPC1 | |
| SCHEMBL13513281 | 0.72 | ALDH1A1 (0.54) | IKBKBCHUKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | claimed |