Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | USP5 | P45974 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541337 | 0.93 | CYP3A4 (0.55) | ALDH1A1KMT2AEPHX2POLBKDM4E | |
| SCHEMBL4535775 | 0.89 | CYP3A4 (0.61) | ALDH1A1KMT2APOLBKDM4EGAA | |
| SCHEMBL4541778 | 0.89 | LMNA (0.58) | ALDH1A1KMT2APOLBKDM4EL3MBTL1 | |
| SCHEMBL4541041 | 0.88 | ALDH1A1 (0.62) | ALDH1A1KMT2AEPHX2KDM4EGAA | |
| SCHEMBL4542840 | 0.86 | PKM (0.57) | ALDH1A1KMT2AEPHX2POLBKDM4E | |
| SCHEMBL4534659 | 0.85 | CYP3A4 (0.53) | ALDH1A1KMT2AEPHX2POLBKDM4E | |
| SCHEMBL4531162 | 0.82 | KMT2A (0.45) | ALDH1A1KMT2AKDM4EL3MBTL1NAMPT | |
| SCHEMBL4535273 | 0.82 | HTT (0.51) | ALDH1A1KMT2APOLBKDM4EGAA | |
| SCHEMBL4532819 | 0.82 | ALDH1A1 (0.49) | ALDH1A1KMT2AEPHX2POLBKDM4E | |
| SCHEMBL4535343 | 0.82 | HTR7 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |