Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535088 | 0.96 | USP30 (0.47) | USP30ALDH1A1L3MBTL1TP53KMT2A | |
| SCHEMBL4541261 | 0.91 | EPHX2 (0.48) | USP30ALDH1A1TP53KMT2AMEN1 | |
| SCHEMBL4537189 | 0.88 | FAAH (0.49) | ALDH1A1L3MBTL1TP53EPHX2ACLY | |
| SCHEMBL4537385 | 0.86 | KMT2A (0.43) | USP30ALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL4539044 | 0.86 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1TP53KMT2AMEN1 | |
| SCHEMBL4539885 | 0.85 | FAAH (0.45) | ALDH1A1L3MBTL1TP53EPHX2 | |
| SCHEMBL4540074 | 0.85 | FBP1 (0.50) | USP30ALDH1A1L3MBTL1TP53KMT2A | |
| SCHEMBL4541720 | 0.83 | POLB (0.43) | USP30 | |
| SCHEMBL4537314 | 0.83 | POLB (0.44) | USP30ALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL4540008 | 0.82 | MEN1 (0.50) | ALDH1A1L3MBTL1TP53KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |