Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.55 |
| ▸ | HTR1B | P28222 | 4/20 | 0.55 |
| ▸ | DRD3 | P35462 | 4/20 | 0.55 |
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | HTR1D | P28221 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | HTR5A | P47898 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533327 | 0.91 | HTR1A (0.52) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL4542139 | 0.89 | PAX8 (0.45) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL4537477 | 0.89 | NCOA1 (0.53) | NCOA1NCOA3RAB9ANPC1 | |
| SCHEMBL4536848 | 0.88 | HTR1A (0.48) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL4535468 | 0.83 | HTR7 (0.59) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL4537510 | 0.83 | RAB9A (0.56) | HTR7SMN1; SMN2NCOA1NCOA3RAB9A | |
| SCHEMBL4537550 | 0.83 | PAX8 (0.56) | HTR7DRD2NPSR1RAB9A | |
| SCHEMBL4541251 | 0.82 | EPHX2 (0.45) | — | |
| SCHEMBL4536836 | 0.80 | BRD4 (0.55) | NCOA1NCOA3RAB9ANPC1 | |
| SCHEMBL8062316 | 0.80 | HTR7 (0.51) | HTR7HTR1BDRD3HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |