Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542594 | 0.96 | MEN1 (0.47) | EPHX2ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL4537192 | 0.89 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1MEN1KMT2ATP53 | |
| SCHEMBL4540074 | 0.89 | FBP1 (0.50) | EPHX2ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL4537967 | 0.88 | ALDH1A1 (0.50) | EPHX2ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL4539993 | 0.88 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL4530586 | 0.86 | EPHX2 (0.52) | EPHX2ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL4540478 | 0.86 | KMT2A (0.50) | ALDH1A1L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL4536853 | 0.85 | EPHX1 (0.49) | EPHX2ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL4542202 | 0.84 | KMT2A (0.49) | ALDH1A1L3MBTL1KMT2ATP53GAA | |
| SCHEMBL4537198 | 0.83 | HTR1A (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |