Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | USP5 | P45974 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537525 | 0.89 | EPHX2 (0.50) | ALDH1A1L3MBTL1KMT2AMAPTMEN1 | |
| SCHEMBL4540074 | 0.89 | FBP1 (0.50) | ALDH1A1POLBL3MBTL1KMT2AMAPT | |
| SCHEMBL4535924 | 0.88 | ALDH1A1 (0.59) | ALDH1A1POLBL3MBTL1NAMPTKMT2A | |
| SCHEMBL4540478 | 0.88 | KMT2A (0.50) | ALDH1A1POLBL3MBTL1KMT2AMAPT | |
| SCHEMBL4539993 | 0.86 | ALDH1A1 (0.51) | ALDH1A1POLBL3MBTL1PKMKMT2A | |
| SCHEMBL4542594 | 0.85 | MEN1 (0.47) | ALDH1A1POLBL3MBTL1NAMPTKMT2A | |
| SCHEMBL4536853 | 0.85 | EPHX1 (0.49) | ALDH1A1POLBL3MBTL1NAMPTKMT2A | |
| SCHEMBL4542924 | 0.84 | CYP3A4 (0.59) | ALDH1A1L3MBTL1NAMPTKMT2AMAPT | |
| SCHEMBL4537541 | 0.82 | ALDH1A1 (0.52) | ALDH1A1POLBL3MBTL1PKMKMT2A | |
| SCHEMBL4535453 | 0.82 | ALDH1A1 (0.56) | ALDH1A1POLBL3MBTL1NAMPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |