Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537171 | 0.91 | RAB9A (0.51) | RAB9ANPC1PAX8 | |
| SCHEMBL4542926 | 0.88 | RAB9A (0.54) | HCRTR1HCRTR2RAB9ANPC1PAX8 | |
| SCHEMBL4537761 | 0.88 | RAB9A (0.46) | RAB9ANPC1PAX8 | |
| SCHEMBL4541692 | 0.85 | RAB9A (0.47) | RAB9ANPC1MCOLN3NCOA1NCOA3 | |
| SCHEMBL4542327 | 0.85 | DRD2 (0.50) | RAB9ADRD2 | |
| SCHEMBL4536862 | 0.84 | ALDH1A1 (0.52) | HCRTR1HCRTR2RAB9ANPC1MCOLN3 | |
| SCHEMBL4540631 | 0.83 | RAB9A (0.51) | HCRTR1HCRTR2RAB9APAX8DRD2 | |
| SCHEMBL4535259 | 0.83 | RAB9A (0.55) | RAB9APAX8NCOA1NCOA3 | |
| SCHEMBL4537004 | 0.82 | RAB9A (0.49) | RAB9APAX8NCOA1NCOA3DRD2 | |
| SCHEMBL4536852 | 0.81 | HTR1A (0.52) | RAB9ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |