Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR1E | P28566 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537065 | 0.86 | TSHR (0.44) | TSHRRAB9ALMNASMN1; SMN2MEN1 | |
| SCHEMBL4541120 | 0.85 | FKBP1A (0.55) | RAB9ALMNAALDH1A1MEN1KMT2A | |
| SCHEMBL4542597 | 0.85 | MAPT (0.45) | TSHRRAB9ASMN1; SMN2MEN1MAPT | |
| SCHEMBL4535937 | 0.85 | PSEN1 (0.58) | RAB9AALDH1A1MAPTPSEN1PSEN2 | |
| SCHEMBL4541106 | 0.84 | VCAM1 (0.48) | NPBWR1MCHR1VCAM1TSHRLMNA | |
| SCHEMBL4542251 | 0.84 | NPBWR1 (0.54) | NPBWR1MCHR1VCAM1LMNASMN1; SMN2 | |
| SCHEMBL4538143 | 0.83 | RAB9A (0.50) | RAB9AALDH1A1MEN1KMT2APSEN1 | |
| SCHEMBL4541044 | 0.83 | CNR1 (0.45) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4538792 | 0.81 | PSEN1 (0.53) | RAB9APOLBPSEN1PSEN2APH1B | |
| SCHEMBL4542334 | 0.81 | PSEN1 (0.53) | RAB9APOLBPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |