Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 2/20 | 0.51 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538117 | 0.88 | FKBP1A (0.48) | FKBP1ALMNANPSR1MEN1KMT2A | |
| SCHEMBL4535199 | 0.86 | MMP1 (0.53) | BDKRB1NPC1RAB9ACNR2HCRTR1 | |
| SCHEMBL4538162 | 0.85 | KMT2A (0.52) | LMNAMEN1KMT2ACNR2FAAH | |
| SCHEMBL4539970 | 0.84 | EPHX2 (0.49) | FKBP1ALMNATSHRMEN1KMT2A | |
| SCHEMBL4542205 | 0.83 | RAB9A (0.52) | BDKRB1NPC1RAB9ACNR2HCRTR1 | |
| SCHEMBL4537168 | 0.82 | RAB9A (0.47) | FKBP1ALMNATSHRNPSR1NPC1 | |
| SCHEMBL4535169 | 0.82 | HTR7 (0.54) | BDKRB1LMNAMEN1KMT2ARAB9A | |
| SCHEMBL4536597 | 0.82 | CYP19A1 (0.54) | FKBP1ALMNAMEN1KMT2ANPC1 | |
| SCHEMBL4540815 | 0.80 | HTT (0.44) | BDKRB1LMNATSHRNPSR1GAA | |
| SCHEMBL4537814 | 0.80 | EPHX2 (0.44) | KMT2ANPC1RAB9ACNR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |