Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 14/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8063549 | 0.91 | HSD11B1 (0.38) | HSD11B1 | |
| SCHEMBL4537224 | 0.88 | P2RX7 (0.43) | — | |
| SCHEMBL8069525 | 0.87 | EPHX2 (0.45) | HSD11B1 | |
| SCHEMBL4530293 | 0.86 | P2RX7 (0.44) | — | |
| SCHEMBL4531364 | 0.85 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL4538974 | 0.84 | CYP19A1 (0.39) | HSD11B1CYP19A1TRPV4 | |
| SCHEMBL4537337 | 0.83 | ATM (0.46) | HSD11B1 | |
| SCHEMBL4542459 | 0.82 | P2RX7 (0.42) | HSD11B1 | |
| SCHEMBL4534371 | 0.80 | DRD2 (0.41) | — | |
| SCHEMBL4542906 | 0.80 | TP53 (0.43) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |