Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.56 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9044328 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL29527960 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL28384900 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL29390111 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Fumaric Acid SCHEMBL11542355 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Fumaric Acid SCHEMBL28362495 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL30291249 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL9044325 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Fumaric Acid SCHEMBL235143 | 0.89 | LMNA (0.50) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL230695 | 0.89 | LMNA (0.50) | TSHRTP53EGLN1EGLN3GABRR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111072474-B | Method for preparing pentaerythritol maleate and preparing heat stabilizer from pentaerythritol maleate | 江南大学 | 2021-11-12 | — | — | CN | claimed |
| CN-111072474-A | Method for preparing pentaerythritol maleate and preparing heat stabilizer from pentaerythritol maleate | 江南大学 | 2020-04-28 | — | — | CN | claimed |
| CN-122029243-A | Antifouling coating composition and antifouling coating film | 日本油漆船舶涂料公司 | 2026-05-12 | — | — | CN | disclosed |
| CN-113912908-B | Polyhydroxy compound salt heat stabilizer and synthetic method and application thereof | 浙江恩普特新材料科技有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-115785474-B | Thiosemicarbazide-terminated pentaerythritol core dendritic polymer and preparation method and corrosion inhibition application thereof | 山东鑫泰水处理技术股份有限公司 | 2023-08-25 | — | — | CN | disclosed |
| CN-115466644-B | Refrigerator oil and working fluid composition | 珠海格力电器股份有限公司 | 2023-06-16 | — | — | CN | disclosed |
| CN-115785474-A | Isothioureido-terminated pentaerythritol core dendritic polymer, and preparation method and corrosion inhibition application thereof | 山东鑫泰水处理技术股份有限公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-115466644-A | Refrigerating machine oil and working fluid composition | 珠海格力电器股份有限公司 | 2022-12-13 | — | — | CN | disclosed |
| CN-113912908-A | Polyhydroxy composite salt heat stabilizer and synthesis method and application thereof | 浙江恩普特新材料科技有限公司 | 2022-01-11 | — | — | CN | disclosed |
| CN-111072474-B | Method for preparing pentaerythritol maleate and preparing heat stabilizer from pentaerythritol maleate | 江南大学 | 2021-11-12 | — | — | CN | disclosed |
| CN-106631779-B | Polyol esters and their use in processing halogenated vinyl polymers | 济南金昌树新材料科技有限公司 | 2020-07-14 | — | — | CN | disclosed |
| CN-111072474-A | Method for preparing pentaerythritol maleate and preparing heat stabilizer from pentaerythritol maleate | 江南大学 | 2020-04-28 | — | — | CN | disclosed |
| US-9981874-B2 | O/W wax dispersions and gypsum products obtainable from these | SASOL WAX GMBH (DE) | 2018-05-29 | — | — | US | disclosed |
| CN-106631779-A | Polyol ester and application of same to processing of halogenated vinyl polymer | 山东金昌树新材料科技有限公司 | 2017-05-10 | — | — | CN | disclosed |
| US-20140245928-A1 | O/W Wax Dispersions and Gypsum Products Obtainable From These | SASOL WAX GMBH (DE) | 2014-09-04 | — | — | US | disclosed |
| US-8741056-B2 | O/W wax dispersions and gypsum products obtainable from these | SASOL WAX GMBH (DE) | 2014-06-03 | — | — | US | disclosed |
| US-20130305962-A1 | O/W Wax Dispersions and Gypsum Products Obtainable From These | SASOL WAX GMBH (DE) | 2013-11-21 | — | — | US | disclosed |
| US-20090194004-A1 | O/W wax dispersions and plaster products obtainable from them | MEYER GERNOT | 2009-08-06 | — | — | US | disclosed |