Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.56 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL29527960 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL28384900 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL29390111 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Fumaric Acid SCHEMBL11542355 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL4539178 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Fumaric Acid SCHEMBL28362495 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL30291249 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL9044325 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Fumaric Acid SCHEMBL235143 | 0.89 | LMNA (0.50) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL230695 | 0.89 | LMNA (0.50) | TSHRTP53EGLN1EGLN3GABRR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497552-B1 | Photopolymerisable compositions | NAT STARCH CHEM INVEST (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5445918-A | Using a photoiniator of a titanocene compound and N-phenyl glycine to polymerize and unsaturated compound; photosensitity; UV and visible radiation | ZENECA LIMITED (GB) | 1995-08-29 | — | — | US | disclosed |
| EP-0497552-A1 | Photopolymerisable compositions | National Starch and Chemical Investment Holding Corporation (US) | 1992-08-05 | — | — | EP | disclosed |