Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535853 | 0.93 | FBP1 (0.46) | HSD11B1FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL8062169 | 0.91 | FBP1 (0.50) | HSD11B1FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL4542443 | 0.91 | FBP1 (0.50) | HSD11B1FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL4539368 | 0.90 | KMT2A (0.46) | HSD11B1FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL4542877 | 0.85 | HSD11B1 (0.44) | HSD11B1FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL8053633 | 0.82 | ALDH1A1 (0.43) | HSD11B1ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL4537989 | 0.81 | P2RX7 (0.46) | HSD11B1ALDH1A1KMT2AP2RX7HPGD | |
| SCHEMBL8048322 | 0.81 | ALDH1A1 (0.45) | HSD11B1ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL4530583 | 0.81 | EPHX2 (0.46) | HSD11B1FBP1ALDH1A1MEN1KMT2A | |
| SCHEMBL4543002 | 0.81 | ALDH1A1 (0.45) | HSD11B1ALDH1A1MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |