Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538146 | 0.95 | CNR1 (0.47) | EPHX2KMT2ALMNAL3MBTL1USP2 | |
| SCHEMBL4541867 | 0.94 | CNR1 (0.51) | EPHX2KMT2ALMNAL3MBTL1USP2 | |
| SCHEMBL4539985 | 0.89 | TSHR (0.50) | KMT2ALMNAL3MBTL1USP2MEN1 | |
| SCHEMBL4542516 | 0.88 | LMNA (0.49) | EPHX2KMT2ALMNAGAAMEN1 | |
| SCHEMBL4540476 | 0.88 | EPHX2 (0.51) | EPHX2KMT2ALMNAL3MBTL1USP2 | |
| SCHEMBL8058688 | 0.87 | KMT2A (0.45) | KMT2ALMNAL3MBTL1CNR1GAA | |
| SCHEMBL8053303 | 0.87 | HSD11B1 (0.52) | KMT2ALMNAUSP2MEN1EPHX1 | |
| SCHEMBL4539809 | 0.87 | HSD11B1 (0.52) | KMT2ALMNAUSP2MEN1EPHX1 | |
| SCHEMBL4537257 | 0.87 | LMNA (0.51) | EPHX2KMT2ALMNAUSP2GAA | |
| SCHEMBL4540431 | 0.86 | NPC1 (0.55) | EPHX2KMT2ALMNAL3MBTL1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |