Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | JAK1 | P23458 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542103 | 0.88 | EPHX2 (0.51) | USP30MAPTL3MBTL1 | |
| SCHEMBL4530586 | 0.85 | EPHX2 (0.52) | MAPTL3MBTL1 | |
| SCHEMBL4543003 | 0.85 | CNR1 (0.48) | TDP1L3MBTL1 | |
| SCHEMBL4535854 | 0.85 | KMT2A (0.47) | MAPTL3MBTL1 | |
| SCHEMBL4542832 | 0.85 | ALDH1A1 (0.54) | L3MBTL1 | |
| SCHEMBL4534333 | 0.83 | PKM (0.50) | MAPTPOLBL3MBTL1 | |
| SCHEMBL4539846 | 0.82 | JAK2 (0.43) | USP30JAK2JAK1POLBL3MBTL1 | |
| SCHEMBL4539837 | 0.82 | MEN1 (0.55) | MAPTPOLB | |
| SCHEMBL4537743 | 0.82 | EPHX2 (0.48) | MAPT | |
| SCHEMBL4539370 | 0.82 | KMT2A (0.48) | MAPTPOLBL3MBTL1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |