Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541310 | 0.93 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1EPHX2EPHX1 | |
| SCHEMBL4535726 | 0.81 | ELOVL6 (0.41) | ALDH1A1L3MBTL1EPHX2MAPK1 | |
| SCHEMBL4539044 | 0.80 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1TP53 | |
| SCHEMBL4535924 | 0.80 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1EPHX2TP53MAPT | |
| SCHEMBL4537967 | 0.80 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1EPHX2TP53 | |
| SCHEMBL4539565 | 0.79 | EPHX2 (0.48) | ALDH1A1L3MBTL1EPHX2EPHX1TP53 | |
| SCHEMBL4537541 | 0.79 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1EPHX2MAPK1 | |
| SCHEMBL4535453 | 0.79 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1EPHX1TP53MAPT | |
| SCHEMBL4537189 | 0.79 | FAAH (0.49) | ALDH1A1L3MBTL1EPHX2TP53 | |
| SCHEMBL4537395 | 0.78 | USP30 (0.50) | ALDH1A1L3MBTL1EPHX2EPHX1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |