Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPTLC1 | O15269 | 1/20 | 0.53 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.41 |
| ▸ | KDM5A | P29375 | 3/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADH5 | P11766 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5351052 | 0.86 | SPTLC1 (0.50) | SPTLC1XDHSLC22A12MAP4K4KDM4C | |
| SCHEMBL455942 | 0.78 | MAP4K4 (0.41) | MAP4K4KDM4CKDM5BKDM5AKDM4A | |
| SCHEMBL6489509 | 0.78 | L3MBTL1 (0.56) | SPTLC1TNKSXDHSLC22A12HDAC6 | |
| SCHEMBL2129234 | 0.76 | TNKS (0.43) | SPTLC1TNKSXDHSLC22A12HDAC6 | |
| SCHEMBL9788686 | 0.74 | TNKS (0.46) | SPTLC1TNKSXDHSLC22A12HDAC6 | |
| SCHEMBL20125121 | 0.74 | ACKR3 (0.43) | SPTLC1TNKSXDHSLC22A12ALDH1A1 | |
| SCHEMBL29740285 | 0.73 | SPTLC1 (0.39) | SPTLC1XDHSLC22A12MAP4K4KDM4C | |
| SCHEMBL25149736 | 0.72 | L3MBTL1 (0.44) | SPTLC1XDHSLC22A12HDAC6KDM4C | |
| SCHEMBL29413476 | 0.72 | MAOB (0.40) | SPTLC1XDHSLC22A12ADH5L3MBTL1 | |
| SCHEMBL5335422 | 0.72 | SPTLC1 (0.45) | SPTLC1XDHSLC22A12HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9238647-B2 | P2X3 receptor antagonists for treatment of pain | MERCK SHARP & DOHME CORP. (US) | 2016-01-19 | — | — | US | disclosed |
| EP-2410857-B1 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME (US) | 2014-01-29 | — | — | EP | disclosed |
| US-20120064181-A1 | P2X3 Receptor Antagonists for Treatment of Pain | MERCK SHARP & DOHME LLC | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064181-A1 | P2X3 Receptor Antagonists for Treatment of Pain | P2RX3, P2RX1, P2RX2 | SPTLC1 3284/4885TNKS 1729/4885XDH 2480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.