Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7529052 | 0.86 | PTGS2 (0.46) | EGFRKDRKMT2AMEN1LMNA | |
| SCHEMBL454627 | 0.85 | EGFR (0.47) | EGFRKDRSRCALDH1A1LMNA | |
| SCHEMBL2152998 | 0.80 | EGFR (0.44) | EGFRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1672138 | 0.78 | CDK1 (0.62) | EGFRALDH1A1LMNAHDAC6CDK1 | |
| SCHEMBL30052313 | 0.78 | CDK1 (0.62) | EGFRALDH1A1LMNAHDAC6CDK1 | |
| SCHEMBL4735463 | 0.74 | CDK1 (0.49) | EGFRALDH1A1LMNAADORA2ATMIGD3 | |
| SCHEMBL23885478 | 0.73 | CDK1 (0.44) | EGFRALDH1A1LMNAADORA2AADORA1 | |
| SCHEMBL30052639 | 0.73 | CDK1 (0.44) | EGFRALDH1A1LMNAADORA2AADORA1 | |
| SCHEMBL6833359 | 0.71 | PDE4A (0.47) | EGFRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1673251 | 0.71 | EGFR (0.70) | EGFRKDRSRCALDH1A1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859490-B2 | Peptide nucleic acid monomers and oligomers | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2014-10-14 | — | — | US | disclosed |
| US-20120065364-A2 | PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2012-03-15 | — | — | US | disclosed |
| US-20110245458-A1 | PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS | NANYANG TECHONOLOGICAL UNIVERSITY (SG) | 2011-10-06 | — | — | US | disclosed |
| WO-2010027326-A1 | PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2010-03-11 | — | — | WO | disclosed |
| US-7115738-B2 | Hydroxyproline/phosphono oligonucleotide analogues, methods of synthesis and methods of use | ACTIVE MOTIF (US) | 2006-10-03 | — | — | US | disclosed |
| US-6962906-B2 | Oligonucleotide analogues, methods of synthesis and methods of use | ACTIVE MOTIF (US) | 2005-11-08 | — | — | US | disclosed |
| EP-1263773-A4 | OLIGONUCLEOTIDE ANALOGUES, METHODS OF SYNTHESIS AND METHODS OF USE | ACTIVE MOTIF (US) | 2005-08-31 | — | — | EP | disclosed |
| EP-1481085-A2 | OLIGONUCLEOTIDE ANALOGUES AND METHODS OF USE FOR MODULATING GENE EXPRESSION | Active Motif (US) | 2004-12-01 | — | — | EP | disclosed |
| US-20040014644-A1 | Oligonucleotide analogues and methods of use for modulating gene expression | ACTIVE MOTIF. | 2004-01-22 | — | — | US | disclosed |
| WO-2003068798-A2 | OLIGONUCLEOTIDE ANALOGUES AND METHODS OF USE FOR MODULATING GENE EXPRESSION | ACTIVE MOTIF (US) | 2003-08-21 | — | — | WO | disclosed |
| US-20030059789-A1 | Oligonucleotide analogues, methods of synthesis and methods of use | ACTIVE MOTIF | 2003-03-27 | — | — | US | disclosed |
| EP-1263773-A1 | OLIGONUCLEOTIDE ANALOGUES, METHODS OF SYNTHESIS AND METHODS OF USE | Active Motif (US) | 2002-12-11 | — | — | EP | disclosed |
| US-20020155989-A1 | Oligonucleotide analogues, methods of synthesis and methods of use | ACTIVE MOTIF | 2002-10-24 | — | — | US | disclosed |
| WO-2001068673-A1 | OLIGONUCLEOTIDE ANALOGUES, METHODS OF SYNTHESIS AND METHODS OF USE | ACTIVE MOTIF (US) | 2001-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065364-A2 | PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS | SIN3A, POLR2H, CYTH3 | EGFR 1810/4885KDR 2253/4885SRC 1941/4885 |
| US-20020155989-A1 | Oligonucleotide analogues, methods of synthesis and methods of use | HIRA, PHAX, SSU72 | EGFR 3441/4885KDR 4384/4885SRC 3052/4885 |
| US-20040014644-A1 | Oligonucleotide analogues and methods of use for modulating gene expression | CRYAA, SRRT, HIRA | EGFR 4515/4885KDR 4421/4885SRC 4092/4885 |
| US-20110245458-A1 | PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS | SIN3A, POLR2H, CYTH3 | EGFR 1810/4885KDR 2253/4885SRC 1941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.