Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10608130 | 0.86 | TSHR (0.59) | TSHRCYP3A4CASP6MAPTCYP1A2 | |
| SCHEMBL20364501 | 0.84 | PDK1 (0.55) | TSHRCYP3A4MEN1KMT2AMAPT | |
| SCHEMBL6234170 | 0.84 | PDK1 (0.44) | TSHRCYP3A4MEN1KMT2AMAPT | |
| SCHEMBL2436243 | 0.84 | TSHR (0.56) | TSHRCYP3A4MEN1KMT2AMAPT | |
| SCHEMBL12381771 | 0.84 | MAPT (0.53) | TSHRCYP3A4MEN1KMT2AMAPT | |
| SCHEMBL5595045 | 0.82 | GPR35 (0.56) | TSHRCYP3A4MEN1KMT2AMAPT | |
| SCHEMBL9886771 | 0.82 | VCAM1 (0.55) | CYP3A4MEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL1455781 | 0.82 | ALDH1A1 (0.50) | TSHRCYP3A4MEN1KMT2AMAPT | |
| SCHEMBL978898 | 0.82 | TSHR (0.59) | TSHRCYP3A4MEN1KMT2AMAPT | |
| SCHEMBL1026668 | 0.82 | ALDH1A1 (0.56) | TSHRMEN1KMT2AMAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9151735-B2 | Cyanine derivatives having meso-reactive functional group at polymethine chain and preparation method thereof | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2015-10-06 | — | — | US | disclosed |
| US-8884032-B2 | Trioxane monomers and dimers | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-11-11 | — | — | US | disclosed |
| US-20140329331-A1 | NOVEL CYANINE DERIVATIVES HAVING MESO-REACTIVE FUNCTIONAL GROUP AT POLYMETHINE CHAIN AND PREPARATION METHOD THEREOF | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2014-11-06 | — | — | US | disclosed |
| US-8344180-B2 | Hydrazine amide derivative | SHIONOGI & CO., LTD. (JP) | 2013-01-01 | — | — | US | disclosed |
| US-8344180-B2 | Hydrazine amide derivative | SHIONOGI & CO., LTD. (JP) | 2013-01-01 | — | — | US | disclosed |
| US-20120108545-A1 | Trioxane Monomers and Dimers | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-05-03 | — | — | US | disclosed |
| US-20100004295-A1 | Hydrazine amide derivative | SHIONOGI & CO., LTD. | 2010-01-07 | — | — | US | disclosed |
| US-20100004295-A1 | Hydrazine amide derivative | SHIONOGI & CO., LTD. | 2010-01-07 | — | — | US | disclosed |
| EP-2062878-A1 | HYDRAZINE AMIDE DERIVATIVE | Shionogi&Co., Ltd. (JP) | 2009-05-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108545-A1 | Trioxane Monomers and Dimers | CDK10, TMSB10, CASP10 | TSHR 1327/4885CYP3A4 561/4885CASP6 767/4885 |
| US-20140329331-A1 | NOVEL CYANINE DERIVATIVES HAVING MESO-REACTIVE FUNCTIONAL GROUP AT POLYMETHINE CHAIN AND PREPARATION METHOD THEREOF | NTRK1, TYR, PARN | TSHR 4179/4885CYP3A4 992/4885CASP6 996/4885 |
| US-20100004295-A1 | Hydrazine amide derivative | NPY5R, NPY1R, NPY2R | TSHR 48/4885CYP3A4 2866/4885CASP6 3074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.