SCHEMBL4548015

SCHEMBL4548015

CN1CCN(C(=O)c2ccc(C(C)(C)C)cc2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 1.00
ALOX15 P16050 1/20 1.00
KMT2A Q03164 6/20 0.78
MEN1 O00255 5/20 0.78
ALDH1A1 P00352 2/20 0.78
HTT P42858 2/20 0.78
SMN1; SMN2 Q16637 2/20 0.78
POLB P06746 4/20 0.65
EPHX2 P34913 1/20 0.59
KDM4E B2RXH2 1/20 0.59
ABL1 P00519 1/20 0.58
BCR P11274 1/20 0.58
CYP1A2 P05177 1/20 0.58
CYP2D6 P10635 1/20 0.58
CYP2C19 P33261 1/20 0.58
LMNA P02545 1/20 0.57
TSHR P16473 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57
GRM5 P41594 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17806552 0.95 HPGD (0.91) HPGDALOX15KMT2AMEN1ALDH1A1
SCHEMBL15317660 0.94 HPGD (0.88) HPGDALOX15KMT2AMEN1ALDH1A1
SCHEMBL17470845 0.89 HPGD (0.79) HPGDALOX15KMT2AMEN1ALDH1A1
SCHEMBL19226469 0.89 KMT2A (0.82) HPGDALOX15KMT2AMEN1ALDH1A1
SCHEMBL17886729 0.87 HPGD (0.76) HPGDALOX15KMT2AMEN1ALDH1A1
SCHEMBL10724841 0.87 POLB (0.81) HPGDALOX15KMT2AMEN1ALDH1A1
SCHEMBL15317655 0.86 MEN1 (0.78) HPGDALOX15KMT2AMEN1ALDH1A1
SCHEMBL270727 0.86 MEN1 (0.90) HPGDALOX15KMT2AMEN1ALDH1A1
SCHEMBL4406614 0.86 MEN1 (0.96) HPGDALOX15KMT2AMEN1ALDH1A1
SCHEMBL14329283 0.85 HPGD (0.74) HPGDALOX15KMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230372297-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES BOEHRINGER INGELHEIM INT (DE) 2023-11-23 US disclosed
US-20230372297-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES BOEHRINGER INGELHEIM INT (DE) 2023-11-23 US disclosed
US-11697650-B2 Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors Eil Therapeutics, Inc. (US) 2023-07-11 US disclosed
US-11697650-B2 Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors Eil Therapeutics, Inc. (US) 2023-07-11 US disclosed
US-20200330435-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES BOEHRINGER INGELHEIM INT (DE) 2020-10-22 US disclosed
US-10752624-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2020-08-25 US disclosed
US-20190233441-A1 TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2019-08-01 US disclosed
US-10273242-B2 Compound inhibiting activities of BTK and/or JAK3 kinases Beijing Hanmi Pharmaceutical Co., Ltd. (CN) 2019-04-30 US disclosed
US-20190038600-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DEISEASES BOEHRINGER INGELHEIM INT (DE) 2019-02-07 US disclosed
US-20180215734-A1 PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS NANTBIOSCIENCE, INC. 2018-08-02 US disclosed
US-20110130406-A1 PYRAZOLO-PYRIDINES AS TYROSINE KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2011-06-02 US disclosed
WO-2010138820-A2 N,N-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2010-12-02 WO disclosed
US-20100256356-A1 HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE ARRAY BIOPHARMA INC. (US) 2010-10-07 US disclosed
US-20100256356-A1 HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE ARRAY BIOPHARMA INC. (US) 2010-10-07 US disclosed
US-20100204211-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-08-12 US disclosed
US-20100204211-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-08-12 US disclosed
US-7723330-B2 Heterobicyclic pyrazole compounds and methods of use ARRAY BIOPHARMA INC. (US) 2010-05-25 US disclosed
US-20070244117-A1 Novel Hydroxamic Acid Esters and Pharmaceutical Use Thereof LEO PHARMA A/S (DK) 2007-10-18 US disclosed
US-20070238726-A1 Heterobicyclic pyrazole compounds and methods of use GENENTECH, INC. 2007-10-11 US disclosed
US-20070197537-A1 Heterobicyclic thiophene compounds and methods of use ARRAY BIOPHARMA, INC. 2007-08-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070197537-A1 Heterobicyclic thiophene compounds and methods of use ERBB2, LCK, SRC HPGD 1640/4885ALOX15 2358/4885KMT2A 4415/4885
US-20100204211-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES MMP1, COL1A1, FOXM1 HPGD 215/4885ALOX15 446/4885KMT2A 4592/4885
US-20180215734-A1 PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS DCK, TK1, DTYMK HPGD 1972/4885ALOX15 3825/4885KMT2A 1204/4885
US-20200330435-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES MMP1, COL1A1, FOXM1 HPGD 215/4885ALOX15 446/4885KMT2A 4592/4885
US-20100256356-A1 HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE ROR1, CYP11B1, CYP11B2 HPGD 842/4885ALOX15 2243/4885KMT2A 4800/4885
US-20110130406-A1 PYRAZOLO-PYRIDINES AS TYROSINE KINASE INHIBITORS TYRO3, LCK, LTK HPGD 1144/4885ALOX15 3124/4885KMT2A 3787/4885
US-20230372297-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES MMP1, COL1A1, SMAD3 HPGD 216/4885ALOX15 463/4885KMT2A 4493/4885
US-20070238726-A1 Heterobicyclic pyrazole compounds and methods of use ROR1, CYP11B1, CYP11B2 HPGD 842/4885ALOX15 2243/4885KMT2A 4800/4885
US-20070244117-A1 Novel Hydroxamic Acid Esters and Pharmaceutical Use Thereof F9, F12, HDAC9 HPGD 301/4885ALOX15 2264/4885KMT2A 1452/4885
US-20190233441-A1 TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF ABL1, JAK2, JAK1 HPGD 994/4885ALOX15 2649/4885KMT2A 1797/4885
US-20190038600-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DEISEASES MMP1, COL1A1, IDO1 HPGD 452/4885ALOX15 855/4885KMT2A 3979/4885
US-10273242-B2 Compound inhibiting activities of BTK and/or JAK3 kinases BTK, JAK3, JAK2 HPGD 4246/4885ALOX15 3165/4885KMT2A 1741/4885
US-11697650-B2 Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors BCL2, BCL2L1, BCL2A1 HPGD 736/4885ALOX15 1756/4885KMT2A 584/4885
US-10752624-B2 Kinase inhibitors LRRK2, MYLK2, MYLK HPGD 4156/4885ALOX15 2780/4885KMT2A 929/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.