Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | EDNRB | P24530 | 2/20 | 0.36 |
| ▸ | EDNRA | P25101 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL406454 | 0.71 | TSHR (0.41) | LMNATSHRSMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL2122975 | 0.70 | ALDH1A1 (0.38) | LMNATSHRSMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL404243 | 0.70 | TSHR (0.40) | LMNATSHRSMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL7787482 | 0.69 | GABRA1 (0.44) | LMNATSHRSMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL407762 | 0.69 | MAPK1 (0.36) | LMNATSHRSMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL2121466 | 0.69 | MAPK1 (0.36) | LMNATSHRSMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL410941 | 0.69 | LMNA (0.38) | LMNATSHRSMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL3027915 | 0.68 | TSHR (0.38) | LMNATSHRSMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL418249 | 0.68 | LMNA (0.38) | LMNATSHRSMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL882732 | 0.68 | PYCR1 (0.47) | LMNATSHRSMN1; SMN2HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054315-A1 | CATHEPSIN S INHIBITOR COMPOUNDS | ELI LILLY AND COMPANY (US) | 2012-04-26 | — | — | WO | disclosed |