Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 4/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553029 | 0.81 | TRPM8 (0.41) | TRPM8PPARG | |
| SCHEMBL3330752 | 0.76 | HDAC4 (0.46) | TRPM8PDK1PDK2PDK3PDK4 | |
| SCHEMBL4582450 | 0.74 | CTRB1 (0.38) | CCR1HSP90AA1HPGDSNPC1RAB9A | |
| SCHEMBL4581842 | 0.74 | ALDH1A1 (0.40) | CCR1HSP90AA1NPC1RAB9A | |
| SCHEMBL13300015 | 0.74 | ATM (0.50) | TRPM8PIN1 | |
| SCHEMBL4583485 | 0.73 | ALDH1A1 (0.47) | CCR1HPGDSNPC1RAB9A | |
| SCHEMBL4374524 | 0.73 | ALDH1A1 (0.47) | CCR1HPGDSNPC1RAB9A | |
| SCHEMBL4377299 | 0.73 | NPC1 (0.45) | BACE1NPC1RAB9A | |
| SCHEMBL4378512 | 0.72 | AKT1 (0.40) | CCR1PIN1 | |
| SCHEMBL4375386 | 0.72 | ACKR3 (0.43) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134175-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121786-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |