Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | CDC25A | P30304 | 6/20 | 0.34 |
| ▸ | CDC25B | P30305 | 6/20 | 0.34 |
| ▸ | CDC25C | P30307 | 5/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798229 | 0.98 | SORT1 (0.56) | SORT1ALDH1A1GAAMAPTTHRB | |
| SCHEMBL11963993 | 0.94 | SORT1 (0.59) | SORT1ALDH1A1GAAMAPTTHRB | |
| SCHEMBL15222747 | 0.73 | SORT1 (0.58) | SORT1NOTUM | |
| SCHEMBL11022532 | 0.71 | SORT1 (0.55) | SORT1ALDH1A1CDC25ACDC25BCDC25C | |
| SCHEMBL452497 | 0.67 | ACHE (0.35) | ALDH1A1GAAMAPTTHRBDHFR | |
| SCHEMBL4887906 | 0.65 | GAA (0.41) | ALDH1A1GAAMAPTTHRBDHFR | |
| SCHEMBL11685919 | 0.64 | DHFR (0.50) | ALDH1A1MAPTTHRBDHFRACHE | |
| SCHEMBL1324152 | 0.64 | MEN1 (0.33) | ALDH1A1GAAMAPTTHRBDHFR | |
| SCHEMBL9662341 | 0.63 | ACHE (0.35) | ALDH1A1THRBDHFRACHEBACE1 | |
| SCHEMBL4611630 | 0.61 | CDC25A (0.44) | ALDH1A1MAPTTHRBACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120100989-A1 | 3-Aryl-4-(2-thienylmethylene)isoxazol-5(4H)-ones as Fungicides | BAYER CROPSCIENCE AG (DE) | 2012-04-26 | — | — | US | claimed |
| US-20120065063-A1 | 3-Aryl-4-(2,6-dimethylbenzylidene)isoxazol-5(4H)-ones as Fungicides | BAYER CROPSCIENCE AG (DE) | 2012-03-15 | — | — | US | claimed |
| JP-3730661-B2 | — | — | 2006-01-05 | — | — | JP | claimed |
| EP-0711270-B1 | Polymers comprising 4-substituted cyclohexane units | COMMW SCIENT IND RES ORG (AU) | 2001-12-19 | — | — | EP | claimed |
| US-5830966-A | Cyclopolymerization monomers and polymers | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-11-03 | — | — | US | claimed |
| EP-0711270-A4 | CYCLOPOLYMERISATION MONOMERS AND POLYMERS | COMMW SCIENT IND RES ORG (AU) | 1997-02-26 | — | — | EP | claimed |
| EP-0711270-A1 | CYCLOPOLYMERISATION MONOMERS AND POLYMERS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 1996-05-15 | — | — | EP | claimed |
| WO-1995004026-A1 | CYCLOPOLYMERISATION MONOMERS AND POLYMERS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 1995-02-09 | — | — | WO | claimed |
| US-20120100989-A1 | 3-Aryl-4-(2-thienylmethylene)isoxazol-5(4H)-ones as Fungicides | BAYER CROPSCIENCE AG (DE) | 2012-04-26 | — | — | US | disclosed |
| US-20120065063-A1 | 3-Aryl-4-(2,6-dimethylbenzylidene)isoxazol-5(4H)-ones as Fungicides | BAYER CROPSCIENCE AG (DE) | 2012-03-15 | — | — | US | disclosed |
| WO-2011161035-A1 | 3-ARYL-4-(2-THIENYLMETHYLENE)-ISOXAZOL-5(4H)-ONES AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2011-12-29 | — | — | WO | disclosed |
| WO-2011161034-A1 | 3-ARYL-4-(2,6-DIMETHYLBENZYLIDENE)-ISOXAZOL-5(4H)-ONES AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2011-12-29 | — | — | WO | disclosed |
| EP-0711270-B1 | Polymers comprising 4-substituted cyclohexane units | COMMW SCIENT IND RES ORG (AU) | 2001-12-19 | — | — | EP | disclosed |
| US-5830966-A | Cyclopolymerization monomers and polymers | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-11-03 | — | — | US | disclosed |
| WO-1995004026-A1 | CYCLOPOLYMERISATION MONOMERS AND POLYMERS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 1995-02-09 | — | — | WO | disclosed |
| WO-1995004109-A1 | AQUEOUS DISPERSIONS CONTAINING CYCLOPOLYMER DISPERSANTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-02-09 | — | — | WO | disclosed |
| EP-0199323-A3 | 4-SUBSTITUTED AMINOALKYLIDENE-3-ARYL-5(4H) ISOXAZOLINES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-10-28 | — | — | EP | disclosed |
| EP-0199323-A3 | 4-SUBSTITUTED AMINOALKYLIDENE-3-ARYL-5(4H) ISOXAZOLINES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-10-28 | — | — | EP | disclosed |
| EP-0199323-A2 | 4-Substituted aminoalkylidene-3-aryl-5(4H) isoxazolines, process for their preparation, medicaments containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-10-29 | — | — | EP | disclosed |
| EP-0199323-A2 | 4-Substituted aminoalkylidene-3-aryl-5(4H) isoxazolines, process for their preparation, medicaments containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120100989-A1 | 3-Aryl-4-(2-thienylmethylene)isoxazol-5(4H)-ones as Fungicides | CYP4X1, CYP4Z1, TH | SORT1 3306/4885ALDH1A1 924/4885GAA 1296/4885 |
| US-20120065063-A1 | 3-Aryl-4-(2,6-dimethylbenzylidene)isoxazol-5(4H)-ones as Fungicides | CYP4X1, CYP4Z1, HAAO | SORT1 3102/4885ALDH1A1 1041/4885GAA 827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.