Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963049 | 0.87 | ERN1 (0.42) | HTR2CHTR2AKDM4EMEN1KMT2A | |
| SCHEMBL963941 | 0.82 | ALDH1A1 (0.51) | HTR2CKDM4EMEN1KMT2AHCRTR1 | |
| SCHEMBL963943 | 0.82 | ALDH1A1 (0.51) | HTR2CKDM4EMEN1KMT2AHCRTR1 | |
| SCHEMBL964737 | 0.71 | PPARG (0.40) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| Potassium Ion SCHEMBL967647 | 0.71 | CNR2 (0.35) | HTR2CALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4554402 | 0.69 | GLS (0.37) | GAAMAPTALDH1A1HPGDNPC1 | |
| SCHEMBL27793964 | 0.68 | MEN1 (0.38) | HTR2CHTR2AKDM4EMEN1KMT2A | |
| SCHEMBL4553928 | 0.68 | CA12 (0.35) | KDM4EMAPTALDH1A1HPGDNPC1 | |
| SCHEMBL964359 | 0.68 | ERN1 (0.43) | KDM4EMEN1KMT2AGAAMAPT | |
| SCHEMBL4554904 | 0.68 | RAB9A (0.34) | KDM4EMEN1KMT2AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |