Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Deoxyguanosine Triphosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.80 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.73 |
| ▸ | P2RY4 | P51582 | 2/20 | 0.73 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.73 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.59 |
| ▸ | TGM2 | P21980 | 1/20 | 0.59 |
| ▸ | KRAS | P01116 | 2/20 | 0.58 |
| ▸ | POLG | P54098 | 1/20 | 0.56 |
| ▸ | NT5E | P21589 | 2/20 | 0.55 |
| ▸ | PNP | P00491 | 1/20 | 0.54 |
| ▸ | DTYMK | P23919 | 4/20 | 0.54 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.50 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.50 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Deoxyguanosine Triphosphate SCHEMBL13111568 | 0.99 | POLB (0.81) | POLBP2RY2P2RY4P2RY6FUT5 | |
| Deoxyguanosine Triphosphate SCHEMBL80609 | 0.99 | POLB (0.81) | POLBP2RY2P2RY4P2RY6FUT5 | |
| Deoxyguanosine Triphosphate SCHEMBL28008515 | 0.99 | POLB (0.81) | POLBP2RY2P2RY4P2RY6FUT5 | |
| Deoxyguanosine Triphosphate SCHEMBL2820367 | 0.99 | POLB (0.81) | POLBP2RY2P2RY4P2RY6FUT5 | |
| Deoxyguanosine Triphosphate SCHEMBL252797 | 0.99 | POLB (0.81) | POLBP2RY2P2RY4P2RY6FUT5 | |
| Deoxyguanosine Triphosphate SCHEMBL18785123 | 0.99 | POLB (0.81) | POLBP2RY2P2RY4P2RY6FUT5 | |
| SCHEMBL3042901 | 0.99 | POLB (0.81) | POLBP2RY2P2RY4P2RY6FUT5 | |
| Deoxyguanosine Triphosphate SCHEMBL12729493 | 0.99 | POLB (0.81) | POLBP2RY2P2RY4P2RY6FUT5 | |
| SCHEMBL16699229 | 0.99 | POLB (0.81) | POLBP2RY2P2RY4P2RY6FUT5 | |
| SCHEMBL18785152 | 0.98 | POLB (0.82) | POLBP2RY2P2RY4P2RY6FUT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590484-B1 | METHOD FOR THE DETECTION OF CYTOSINE METHYLATION PATTERNS WITH HIGH SENSITIVITY | EPIGENOMICS AG (DE) | 2009-08-19 | — | — | EP | claimed |