Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.30 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.30 |
| ▸ | FASN | P49327 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565595 | 0.93 | KCNH2 (0.34) | IRAK4SYKMETPIK3C3KCNH2 | |
| SCHEMBL4565426 | 0.86 | TGFBR1 (0.38) | PIK3C3ALK | |
| SCHEMBL4565577 | 0.76 | SGK1 (0.46) | — | |
| SCHEMBL4564364 | 0.76 | HTR6 (0.36) | FASN | |
| SCHEMBL4564399 | 0.73 | FASN (0.37) | KCNH2FASN | |
| SCHEMBL4565553 | 0.73 | FGFR1 (0.37) | SYK | |
| SCHEMBL4565405 | 0.73 | PTGER3 (0.34) | FASN | |
| SCHEMBL4541625 | 0.73 | FASN (0.38) | FASN | |
| SCHEMBL4536541 | 0.72 | — | — | |
| SCHEMBL4561931 | 0.72 | FASN (0.41) | FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | disclosed |