Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 12/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.31 |
| ▸ | FASN | P49327 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565379 | 0.93 | IRAK4 (0.34) | KCNH2ALKSYKPIK3C3RIPK3 | |
| SCHEMBL4565426 | 0.88 | TGFBR1 (0.38) | ALKPIK3C3MAP4K4TGFBR1 | |
| SCHEMBL4564364 | 0.82 | HTR6 (0.36) | FASN | |
| SCHEMBL4565577 | 0.78 | SGK1 (0.46) | — | |
| SCHEMBL4565605 | 0.75 | MAPK14 (0.37) | FASN | |
| SCHEMBL4564596 | 0.75 | CD74 (0.34) | — | |
| SCHEMBL4564399 | 0.75 | FASN (0.37) | KCNH2FASN | |
| SCHEMBL4565405 | 0.75 | PTGER3 (0.34) | FASN | |
| SCHEMBL4565553 | 0.75 | FGFR1 (0.37) | SYKFLT3AURKBMAP4K4 | |
| SCHEMBL4541625 | 0.74 | FASN (0.38) | FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | disclosed |