SCHEMBL4569587

SCHEMBL4569587

Cc1ccc(Oc2c(F)c(F)c(C)c(F)c2F)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TEAD4 Q15561 1/20 0.45
MAPT P10636 4/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
POLB P06746 2/20 0.43
TDP1 Q9NUW8 2/20 0.43
ALDH1A1 P00352 1/20 0.43
LMNA P02545 3/20 0.42
ACHE P22303 3/20 0.41
HSD17B10 Q99714 1/20 0.41
HTT P42858 3/20 0.39
HPGD P15428 1/20 0.39
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA7 P43166 1/20 0.38
CA13 Q8N1Q1 1/20 0.38
HSP90AA1 P07900 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.36
NPSR1 Q6W5P4 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14424439 0.86 HSD17B10 (0.43) TEAD4MAPTMEN1KMT2APOLB
SCHEMBL12770812 0.86 LMNA (0.44) TEAD4MAPTMEN1KMT2APOLB
SCHEMBL15801333 0.83 TEAD4 (0.69) TEAD4MAPTMEN1KMT2APOLB
SCHEMBL12238333 0.82 TEAD4 (0.41) TEAD4MAPTMEN1KMT2APOLB
SCHEMBL15801331 0.79 TEAD4 (0.62) TEAD4MAPTMEN1KMT2APOLB
SCHEMBL3874015 0.78 TEAD4 (0.59) TEAD4MAPTMEN1KMT2APOLB
SCHEMBL10022966 0.77 HSD17B10 (0.38) MAPTMEN1KMT2APOLBLMNA
SCHEMBL25836661 0.77 PTGS2 (0.49) HTTHPGDCA12CA1CA2
SCHEMBL7870128 0.77 ALDH1A1 (0.43) TEAD4MAPTMEN1KMT2APOLB
SCHEMBL13952954 0.76 ESR2 (0.40) MEN1KMT2AALDH1A1ACHECA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9178238-B2 Rubber crack mitigants in polyelectrolyte membranes GM GLOBAL TECHNOLOGY OPERATIONS, LLC (US) 2015-11-03 US disclosed
US-9178238-B2 Rubber crack mitigants in polyelectrolyte membranes GM GLOBAL TECHNOLOGY OPERATIONS, LLC (US) 2015-11-03 US disclosed
US-9172099-B2 Nano-fibers for electrical power generation GM Global Technology Operations LLC (US) 2015-10-27 US disclosed
US-9172099-B2 Nano-fibers for electrical power generation GM Global Technology Operations LLC (US) 2015-10-27 US disclosed
US-20150171454-A1 MEMBRANE WITH LAMINATED STRUCTURE AND ORIENTATION CONTROLLED NANOFIBER REINFORCEMENT ADDITIVES FOR FUEL CELLS GM GLOBAL TECH OPERATIONS INC (US) 2015-06-18 US disclosed
US-20150171454-A1 MEMBRANE WITH LAMINATED STRUCTURE AND ORIENTATION CONTROLLED NANOFIBER REINFORCEMENT ADDITIVES FOR FUEL CELLS GM GLOBAL TECH OPERATIONS INC (US) 2015-06-18 US disclosed
US-9040209-B2 Multi-layer polyelectrolyte membranes GM Global Technology Operations LLC (US) 2015-05-26 US disclosed
US-9040209-B2 Multi-layer polyelectrolyte membranes GM Global Technology Operations LLC (US) 2015-05-26 US disclosed
US-8735021-B2 Cobalt(II) tetramethoxyphenylporphyrin (CoTMPP) ionomer stabilization to prevent electrode degradation GM Global Technology Operations LLC (US) 2014-05-27 US disclosed
US-8735021-B2 Cobalt(II) tetramethoxyphenylporphyrin (CoTMPP) ionomer stabilization to prevent electrode degradation GM Global Technology Operations LLC (US) 2014-05-27 US disclosed
US-7888433-B2 Sulfonated-polyperfluoro-cyclobutane-polyphenylene polymers for PEM fuel cell applications GM GLOBAL TECHNOLOGY OPERATIONS, INC. (US) 2011-02-15 US disclosed
US-7888433-B2 Sulfonated-polyperfluoro-cyclobutane-polyphenylene polymers for PEM fuel cell applications GM GLOBAL TECHNOLOGY OPERATIONS, INC. (US) 2011-02-15 US disclosed
US-20100047657-A1 GRADIENT REINFORCED PROTON EXCHANGE MEMBRANE GM GLOBAL TECHNOLOGY OPERATIONS, INC. (US) 2010-02-25 US disclosed
US-20100047657-A1 GRADIENT REINFORCED PROTON EXCHANGE MEMBRANE GM GLOBAL TECHNOLOGY OPERATIONS, INC. (US) 2010-02-25 US disclosed
US-20090280383-A1 BLENDED PEM'S WITH ELASTOMERS FOR IMPROVED MECHANICAL DURABILITY GM GLOBAL TECHNOLOGY OPERATIONS, INC. (US) 2009-11-12 US disclosed
US-20090281270-A1 SULFONATED-POLYPERFLUORO-CYCLOBUTANE-POLYPHENLENE POLYMERS FOR PEM FUEL CELL APPLICATIONS GM GLOBAL TECHNOLOGY OPERATIONS, INC. (US) 2009-11-12 US disclosed
US-20090281262-A1 PROTON CONDUCTIVE POLYMER ELECTROLYTES AND FUEL CELLS GM GLOBAL TECHNOLOGY OPERATIONS, INC. (US) 2009-11-12 US disclosed
US-20090281262-A1 PROTON CONDUCTIVE POLYMER ELECTROLYTES AND FUEL CELLS GM GLOBAL TECHNOLOGY OPERATIONS, INC. (US) 2009-11-12 US disclosed
US-20090278083-A1 POLYELECTROLYTE MEMBRANES COMPRISED OF BLENDS OF PFSA AND SULFONATED PFCB POLYMERS GM GLOBAL TECHNOLOGY OPERATIONS, INC. (US) 2009-11-12 US disclosed
US-20090280382-A1 COMPOSITE MEMBRANE GM GLOBAL TECHNOLOGY OPERATIONS, INC. (US) 2009-11-12 US disclosed