Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 12/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 11/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 11/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 7/20 | 0.39 |
| ▸ | HSPE1 | P61604 | 7/20 | 0.39 |
| ▸ | MMP8 | P22894 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | FASN | P49327 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565426 | 0.71 | TGFBR1 (0.38) | — | |
| SCHEMBL4564364 | 0.70 | HTR6 (0.36) | FASN | |
| SCHEMBL4564770 | 0.68 | NR3C1 (0.33) | — | |
| SCHEMBL24295077 | 0.66 | PTPN1 (0.63) | PTPN1PTPN5PTPN2MEN1HPGD | |
| SCHEMBL4564697 | 0.66 | CHRNA7 (0.33) | FASN | |
| SCHEMBL4565386 | 0.65 | FASN (0.40) | FASN | |
| SCHEMBL8120431 | 0.65 | PTPN1 (0.64) | PTPN1PTPN5PTPN2MEN1HPGD | |
| SCHEMBL31170 | 0.63 | NPC1 (0.81) | PTPN1PTPN5PTPN2MEN1HPGD | |
| SCHEMBL13994723 | 0.62 | PTPN1 (0.57) | PTPN1PTPN5PTPN2MEN1HPGD | |
| SCHEMBL31476 | 0.61 | NPC1 (0.79) | PTPN1PTPN5PTPN2MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | disclosed |