Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.51 |
| ▸ | ITK | Q08881 | 8/20 | 0.48 |
| ▸ | BTK | Q06187 | 7/20 | 0.48 |
| ▸ | AXL | P30530 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7872452 | 0.89 | AAK1 (0.51) | AAK1RIPK1ITKBTKAXL | |
| SCHEMBL4570630 | 0.86 | BTK (0.48) | AAK1RIPK1ITKBTKAXL | |
| SCHEMBL4570626 | 0.81 | CAMKK2 (0.61) | AAK1RIPK1ITKAXLBRD4 | |
| SCHEMBL7879449 | 0.79 | RIPK1 (0.47) | AAK1RIPK1ITKBTKAXL | |
| SCHEMBL4570621 | 0.78 | PAK1 (0.57) | AAK1BRD4PAK4 | |
| SCHEMBL411513 | 0.77 | RIPK1 (0.59) | AAK1RIPK1ITKBTKBRD4 | |
| SCHEMBL10292989 | 0.77 | NTRK1 (0.60) | AAK1RIPK1ITKBTKNTRK1 | |
| SCHEMBL4570622 | 0.77 | BRAF (0.49) | AAK1RIPK1AXLBRD4CYP3A4 | |
| SCHEMBL4570635 | 0.77 | AAK1 (0.47) | AAK1AXLBRD4CYP3A4CDK2 | |
| SCHEMBL4570634 | 0.77 | AAK1 (0.47) | AAK1ITKAXLBRD4PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | BRAF, RAF1, ARAF | AAK1 247/4885RIPK1 637/4885ITK 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.