Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15648413 | 0.84 | KMT2A (0.51) | CYP4F2CYP4A11MAOBKMT2AMAPT | |
| SCHEMBL457587 | 0.83 | AKR1C3 (0.47) | KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL456458 | 0.82 | NR4A2 (0.42) | CYP4F2CYP4A11MAOBKMT2AMAPT | |
| SCHEMBL15093989 | 0.82 | MMP1 (0.43) | MAOBFFAR1FFAR4 | |
| SCHEMBL15094248 | 0.79 | MAOB (0.44) | DAOMAOBHPGDALDH1A1FFAR1 | |
| SCHEMBL455030 | 0.78 | KMT2A (0.59) | KMT2AMAPTMEN1HPGDALDH1A1 | |
| SCHEMBL457499 | 0.77 | GPR84 (0.51) | GPR84DAOMAOBKMT2ATHRA | |
| SCHEMBL8656536 | 0.76 | L3MBTL1 (0.45) | KMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL8914213 | 0.76 | CYP4F2 (0.51) | CYP4F2CYP4A11KMT2AMAPTMEN1 | |
| SCHEMBL457502 | 0.76 | SLC5A1 (0.55) | GPR84CYP4F2CYP4A11KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10800725-B2 | Arylpropionyl-triketone antibacterial agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-10-13 | — | — | US | disclosed |
| US-9517994-B2 | Antibacterial agents: phloroglucinol derivatives | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-12-13 | — | — | US | disclosed |
| US-20150011647-A1 | ANTIBACTERIAL AGENTS: PHLOROGLUCINOL DERIVATIVES | HOWARD HUGHES MEDICAL INSTITUTE | 2015-01-08 | — | — | US | disclosed |
| US-20130289128-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-10-31 | — | — | US | disclosed |
| WO-2013103969-A1 | ANTIBACTERIAL AGENTS: PHLOROGLUCINOL DERIVATIVES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2013-07-11 | — | — | WO | disclosed |
| WO-2012033846-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130289128-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | POLR2H, POLR2A, POLR2E | GPR84 3816/4885CYP4F2 3930/4885CYP4A11 3664/4885 |
| US-20150011647-A1 | ANTIBACTERIAL AGENTS: PHLOROGLUCINOL DERIVATIVES | BET1, MRPL21, PHF6 | GPR84 4030/4885CYP4F2 2834/4885CYP4A11 3893/4885 |
| US-10800725-B2 | Arylpropionyl-triketone antibacterial agents | POLR2H, POLR2A, POLR2E | GPR84 3816/4885CYP4F2 3930/4885CYP4A11 3664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.