Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28121829 | 0.85 | MTNR1A (0.51) | AKR1C3AKR1C2NPC1RAB9AMTNR1A | |
| SCHEMBL15094266 | 0.85 | POLB (0.52) | NPC1RAB9APKMMEN1KMT2A | |
| SCHEMBL28968062 | 0.84 | KMT2A (0.60) | AKR1C3AKR1C2NPC1RAB9AMTNR1A | |
| SCHEMBL457074 | 0.83 | GPR84 (0.46) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL31321708 | 0.82 | L3MBTL1 (0.56) | AKR1C3AKR1C2MTNR1AMTNR1BMEN1 | |
| SCHEMBL28968071 | 0.82 | NPC1 (0.54) | AKR1C3AKR1C2NPC1RAB9AMTNR1A | |
| SCHEMBL19160433 | 0.81 | TAAR1 (0.51) | AKR1C3AKR1C2NPC1RAB9AMTNR1A | |
| SCHEMBL456458 | 0.80 | NR4A2 (0.42) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL31321639 | 0.80 | NPC1 (0.55) | AKR1C3AKR1C2NPC1RAB9AMTNR1A | |
| SCHEMBL16861294 | 0.79 | MTNR1A (0.57) | MTNR1AMTNR1BMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10800725-B2 | Arylpropionyl-triketone antibacterial agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-10-13 | — | — | US | disclosed |
| US-9517994-B2 | Antibacterial agents: phloroglucinol derivatives | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-12-13 | — | — | US | disclosed |
| US-20150011647-A1 | ANTIBACTERIAL AGENTS: PHLOROGLUCINOL DERIVATIVES | HOWARD HUGHES MEDICAL INSTITUTE | 2015-01-08 | — | — | US | disclosed |
| US-20130289128-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-10-31 | — | — | US | disclosed |
| WO-2013103969-A1 | ANTIBACTERIAL AGENTS: PHLOROGLUCINOL DERIVATIVES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2013-07-11 | — | — | WO | disclosed |
| WO-2012033846-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130289128-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | POLR2H, POLR2A, POLR2E | AKR1C3 490/4885AKR1C2 611/4885NPC1 2693/4885 |
| US-20150011647-A1 | ANTIBACTERIAL AGENTS: PHLOROGLUCINOL DERIVATIVES | BET1, MRPL21, PHF6 | AKR1C3 760/4885AKR1C2 1588/4885NPC1 3367/4885 |
| US-10800725-B2 | Arylpropionyl-triketone antibacterial agents | POLR2H, POLR2A, POLR2E | AKR1C3 490/4885AKR1C2 611/4885NPC1 2693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.