Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | HEXA | P06865 | 1/20 | 0.34 |
| ▸ | HEXB | P07686 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599658 | 0.78 | HEXA (0.41) | RAB9AHEXAHEXBKDM4ENPC1 | |
| SCHEMBL7469061 | 0.75 | KDM4E (0.41) | SMN1; SMN2L3MBTL1ADORA3ADORA2AADORA1 | |
| SCHEMBL2097244 | 0.72 | DCUN1D1 (0.41) | SMN1; SMN2TNKS2NR1H2NR1H3RAB9A | |
| SCHEMBL6497018 | 0.68 | ALDH1A1 (0.50) | SMN1; SMN2TP53ADORA3RAB9AALDH1A1 | |
| SCHEMBL457222 | 0.64 | SMN1; SMN2 (0.56) | SMN1; SMN2TP53L3MBTL1ADORA3ADORA2A | |
| SCHEMBL1696584 | 0.64 | NR1H2 (0.66) | SMN1; SMN2TP53ADORA2ANR1H2NR1H3 | |
| SCHEMBL1696508 | 0.63 | TP53 (0.53) | SMN1; SMN2TP53L3MBTL1ADORA3ADORA2A | |
| SCHEMBL458788 | 0.63 | BTK (0.36) | SMN1; SMN2TP53L3MBTL1ADORA3ADORA2A | |
| SCHEMBL5378775 | 0.63 | KDM4E (0.59) | SMN1; SMN2TP53L3MBTL1ALDH1A1MAPT | |
| SCHEMBL19116734 | 0.63 | L3MBTL1 (0.61) | SMN1; SMN2TP53L3MBTL1ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614053-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012033225-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-03-15 | — | — | WO | disclosed |