Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 10/20 | 0.40 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1773395 | 0.79 | DRD2 (0.51) | LMNASMN1; SMN2MAPTGAAMCL1 | |
| SCHEMBL12355741 | 0.79 | LMNA (0.40) | LMNASMN1; SMN2MAPTGAAMCL1 | |
| SCHEMBL9114944 | 0.75 | MAPT (0.38) | LMNASMN1; SMN2MAPTGAAMCL1 | |
| SCHEMBL30133223 | 0.72 | KMT2A (0.50) | LMNASMN1; SMN2MAPTGAAMCL1 | |
| SCHEMBL23721149 | 0.71 | MAPT (0.36) | LMNASMN1; SMN2MAPTGAAMCL1 | |
| SCHEMBL8718926 | 0.71 | GAA (0.62) | LMNASMN1; SMN2MAPTGAAMCL1 | |
| SCHEMBL12208493 | 0.70 | DRD2 (0.61) | LMNASMN1; SMN2MAPTGAAMCL1 | |
| SCHEMBL10761480 | 0.68 | LMNA (0.36) | LMNASMN1; SMN2MAPTGAAMCL1 | |
| SCHEMBL7507906 | 0.67 | ALDH1A1 (0.61) | LMNASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL15943307 | 0.67 | RAB9A (0.47) | LMNASMN1; SMN2MAPTGAAMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |