Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 8/20 | 0.39 |
| ▸ | CNR1 | P21554 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL621869 | 0.81 | POLB (0.71) | NPC1RAB9AATMPOLBCNR2 | |
| SCHEMBL744546 | 0.81 | LMNA (0.46) | POLBKMT2AHTT | |
| SCHEMBL6023280 | 0.80 | NPC1 (0.54) | NPC1RAB9AATMPOLBCNR2 | |
| SCHEMBL706443 | 0.80 | HDAC1 (0.58) | NPC1RAB9AATMPOLB | |
| SCHEMBL10123127 | 0.80 | RAB9A (0.54) | NPC1RAB9AATMPOLBCNR2 | |
| SCHEMBL9307990 | 0.79 | KDM4E (0.53) | NPC1RAB9AATMPOLBCNR2 | |
| SCHEMBL3750397 | 0.79 | POLB (0.54) | NPC1RAB9AATMPOLBCNR2 | |
| SCHEMBL4240834 | 0.79 | OGG1 (0.53) | NPC1RAB9AATMPOLBKMT2A | |
| SCHEMBL3757683 | 0.79 | NPC1 (0.52) | NPC1RAB9AATMPOLBCNR2 | |
| SCHEMBL11074386 | 0.79 | NPC1 (0.52) | NPC1RAB9AATMPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8729089-B2 | Pyrido(3,2-d)pyrimidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2014-05-20 | — | — | US | claimed |
| US-20080221147-A1 | Method of inhibiting neurotrophin-receptor binding | ROSS GREGORY M | 2008-09-11 | — | — | US | claimed |
| US-20080182870-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-31 | — | — | US | claimed |
| WO-2008077651-A1 | PYRIDO(3,2-D)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-03 | — | — | WO | claimed |
| US-8729089-B2 | Pyrido(3,2-d)pyrimidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20080221147-A1 | Method of inhibiting neurotrophin-receptor binding | ROSS GREGORY M | 2008-09-11 | — | — | US | disclosed |
| US-20080182870-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-31 | — | — | US | disclosed |
| WO-2008077651-A1 | PYRIDO(3,2-D)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
| EP-1743886-A1 | Method of inhibiting neurotrophin-receptor binding | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2007-01-17 | — | — | EP | disclosed |
| US-20060063793-A1 | Method of inhibiting neurotrophin-receptor binding | ROSS GREGORY M | 2006-03-23 | — | — | US | disclosed |
| US-20030203923-A1 | Method of inhibiting neurotrophin-receptor binding | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2003-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063793-A1 | Method of inhibiting neurotrophin-receptor binding | NGF, NTRK2, BDNF | NPC1 3769/4885RAB9A 3720/4885ATM 4577/4885 |
| US-20030203923-A1 | Method of inhibiting neurotrophin-receptor binding | NGF, NTRK2, BDNF | NPC1 4064/4885RAB9A 4136/4885ATM 4660/4885 |
| US-20080221147-A1 | Method of inhibiting neurotrophin-receptor binding | NGF, NTRK2, BDNF | NPC1 3769/4885RAB9A 3720/4885ATM 4577/4885 |
| US-20080182870-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | PNPO, DPYD, PNP | NPC1 2244/4885RAB9A 2543/4885ATM 4620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.