Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1251842 | 0.81 | EPHX2 (0.49) | EPHX2NR1H4ENPP2PTGS2CA12 | |
| SCHEMBL1253851 | 0.79 | EPHX2 (0.47) | EPHX2NR1H4ENPP2PTGS2PTGS1 | |
| Hydrochloric Acid SCHEMBL1287377 | 0.79 | KDM4E (0.50) | EPHX2NR1H4ENPP2PTGS2CA12 | |
| SCHEMBL14508573 | 0.78 | EPHX2 (0.46) | EPHX2NR1H4ENPP2CA12CA1 | |
| SCHEMBL3930626 | 0.77 | EPHX2 (0.57) | EPHX2NR1H4ENPP2CA1CA2 | |
| SCHEMBL13263443 | 0.77 | EPHX2 (0.54) | EPHX2NR1H4ENPP2CA1CA2 | |
| SCHEMBL3301007 | 0.76 | EPHX2 (0.45) | EPHX2NR1H4ENPP2PTGS2CA12 | |
| SCHEMBL568156 | 0.76 | ADH1B (0.53) | EPHX2NR1H4ENPP2PTGS2CA12 | |
| SCHEMBL13090066 | 0.76 | EPHX2 (0.53) | EPHX2NR1H4ENPP2PTGS2PTGS1 | |
| SCHEMBL21165326 | 0.76 | CA2 (0.66) | PTGS2PTGS1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200454-A1 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2008-08-21 | — | — | US | claimed |
| WO-2008100618-A2 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | claimed |
| EP-1887007-A2 | Novel compounds | AstraZeneca AB (SE) | 2008-02-13 | — | — | EP | claimed |
| US-20060287355-A1 | Imidazo and thiazolopyridines as jak3 kinase inhibitors | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | US | claimed |
| US-20080200454-A1 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2008-08-21 | — | — | US | disclosed |
| WO-2008100618-A2 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
| EP-1887007-A2 | Novel compounds | AstraZeneca AB (SE) | 2008-02-13 | — | — | EP | disclosed |
| EP-1625126-B1 | IMIDAZO AND THIAZOLOPYRIDINES AS JAK3 KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-01-16 | — | — | EP | disclosed |
| US-20060287355-A1 | Imidazo and thiazolopyridines as jak3 kinase inhibitors | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | US | disclosed |
| EP-1625126-A1 | IMIDAZO AND THIAZOLOPYRIDINES AS JAK3 KINASE INHIBITORS | AstraZeneca AB (SE) | 2006-02-15 | — | — | EP | disclosed |
| WO-2004099204-A1 | IMIDAZO AND THIAZOLOPYRIDINES AS JAK3 KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200454-A1 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | CTSS, CTSK, CTSZ | EPHX2 3129/4885NR1H4 1417/4885ENPP2 229/4885 |
| US-20060287355-A1 | Imidazo and thiazolopyridines as jak3 kinase inhibitors | JAK3, JAK2, JAK1 | EPHX2 4174/4885NR1H4 2754/4885ENPP2 3966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.