Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 15/20 | 0.63 |
| ▸ | CTSS | P25774 | 15/20 | 0.63 |
| ▸ | CTSK | P43235 | 15/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590334 | 0.81 | CTSB (0.44) | CTSBCTSSCTSK | |
| SCHEMBL4590328 | 0.81 | CTSB (0.44) | CTSBCTSSCTSK | |
| SCHEMBL4574398 | 0.70 | CTSB (0.54) | CTSBCTSSCTSKFAAHCCR1 | |
| SCHEMBL4573010 | 0.70 | CTSB (0.54) | CTSBCTSSCTSKFAAHCCR1 | |
| SCHEMBL4788689 | 0.69 | PDE4B (0.46) | — | |
| SCHEMBL4573200 | 0.67 | CTSK (0.57) | CTSBCTSSCTSK | |
| SCHEMBL4586118 | 0.67 | CTSB (0.42) | CTSBCTSSCTSK | |
| SCHEMBL4589748 | 0.65 | CTSB (0.54) | CTSBCTSSCTSK | |
| SCHEMBL4585200 | 0.65 | CTSB (0.54) | CTSBCTSSCTSKCHRM4FAAH | |
| SCHEMBL4573253 | 0.65 | CTSK (0.39) | CTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |