Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 7/20 | 0.42 |
| ▸ | CTSS | P25774 | 7/20 | 0.42 |
| ▸ | CTSK | P43235 | 7/20 | 0.42 |
| ▸ | RORC | P51449 | 12/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573200 | 0.86 | CTSK (0.57) | CTSBCTSSCTSKKCNH2 | |
| SCHEMBL4589748 | 0.85 | CTSB (0.54) | CTSBCTSSCTSKKCNH2 | |
| SCHEMBL4573939 | 0.83 | SLC6A9 (0.48) | CTSBCTSSCTSKKCNH2 | |
| SCHEMBL4573950 | 0.79 | CTSS (0.45) | CTSBCTSSCTSKKCNH2 | |
| SCHEMBL4573119 | 0.78 | SLC6A9 (0.40) | CTSBCTSSCTSKKCNH2 | |
| SCHEMBL4573015 | 0.77 | CTSK (0.38) | CTSBCTSSCTSKKCNH2 | |
| SCHEMBL4573253 | 0.76 | CTSK (0.39) | CTSBCTSSCTSKKCNH2 | |
| SCHEMBL8107852 | 0.75 | CTSK (0.75) | CTSBCTSSCTSKKCNH2 | |
| SCHEMBL4790305 | 0.72 | USP30 (0.41) | CTSBCTSSCTSK | |
| SCHEMBL4584329 | 0.70 | HRH3 (0.40) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |