Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 13/20 | 0.54 |
| ▸ | CTSK | P43235 | 13/20 | 0.54 |
| ▸ | CTSS | P25774 | 9/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573200 | 0.97 | CTSK (0.57) | CTSBCTSKCTSSAKR1C3KCNH2 | |
| SCHEMBL4573950 | 0.86 | CTSS (0.45) | CTSBCTSKCTSSKCNH2CTSL | |
| SCHEMBL4586118 | 0.85 | CTSB (0.42) | CTSBCTSKCTSSKCNH2 | |
| SCHEMBL4573939 | 0.83 | SLC6A9 (0.48) | CTSBCTSKCTSSKCNH2SLC6A9 | |
| SCHEMBL4573253 | 0.80 | CTSK (0.39) | CTSBCTSKCTSSKCNH2 | |
| SCHEMBL4573015 | 0.79 | CTSK (0.38) | CTSBCTSKCTSSKCNH2HRH3 | |
| SCHEMBL4790305 | 0.78 | USP30 (0.41) | CTSBCTSKCTSSCTSLCYP3A4 | |
| SCHEMBL4573119 | 0.77 | SLC6A9 (0.40) | CTSBCTSKCTSSKCNH2SLC6A9 | |
| SCHEMBL4589750 | 0.74 | CTSK (0.94) | CTSBCTSKCTSSKCNH2CTSL | |
| SCHEMBL8113806 | 0.70 | CTSK (1.00) | CTSBCTSKCTSSKCNH2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |