Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590115 | 0.81 | SIGMAR1 (0.40) | RIPK1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4574566 | 0.81 | SIGMAR1 (0.40) | RIPK1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL14013142 | 0.74 | RIPK1 (0.33) | RIPK1 | |
| SCHEMBL4574455 | 0.72 | KDM4E (0.44) | KDM4ESMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL2022959 | 0.72 | XIAP (0.40) | — | |
| SCHEMBL5238513 | 0.70 | BCHE (0.44) | ALDH1A1 | |
| SCHEMBL4573906 | 0.70 | RIPK1 (0.37) | RIPK1DPP4FAPDPP8DPP9 | |
| SCHEMBL4590377 | 0.69 | MLNR (0.42) | RIPK1KDM4ESMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL4573863 | 0.69 | SCN9A (0.36) | RIPK1KDM4ESMN1; SMN2 | |
| SCHEMBL14013388 | 0.69 | SCN9A (0.36) | RIPK1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134035-A1 | ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
| WO-2008134035-A1 | ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |