Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | AGXT | P21549 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25428289 | 0.94 | KIF11 (0.67) | KIF11JAK2TSHRMAPK1ALDH1A1 | |
| SCHEMBL11415271 | 0.85 | KIF11 (0.46) | KIF11JAK2AGXTENPP1KIT | |
| SCHEMBL17840160 | 0.81 | KIF11 (0.68) | KIF11JAK2TSHRALDH1A1MAOB | |
| SCHEMBL4453287 | 0.81 | TSHR (0.47) | KIF11JAK2TSHRMAPK1MAOB | |
| SCHEMBL398877 | 0.81 | ALDH1A1 (0.58) | KIF11JAK2TSHRALDH1A1MKNK1 | |
| SCHEMBL8025255 | 0.79 | KIF11 (0.65) | KIF11JAK2TSHRALDH1A1MAOB | |
| Fluoride SCHEMBL9251966 | 0.79 | ALDH1A1 (0.56) | KIF11JAK2TSHRALDH1A1MKNK1 | |
| Hydrochloric Acid SCHEMBL2846560 | 0.79 | ALDH1A1 (0.56) | KIF11JAK2TSHRALDH1A1MAOB | |
| SCHEMBL5647970 | 0.79 | KIF11 (0.47) | KIF11JAK2TSHRMAPK1ALDH1A1 | |
| SCHEMBL1092188 | 0.78 | NPC1 (0.50) | KIF11TSHRMAPK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319084-B2 | Catalysts containing N-pyrrolyl substituted nitrogen donors | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319084-B2 | Catalysts containing N-pyrrolyl substituted nitrogen donors | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319084-B2 | Catalysts containing N-pyrrolyl substituted nitrogen donors | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-01-15 | — | — | US | disclosed |
| US-20060178490-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | E. I. DU PONT DE NEMOURS AND COMPANY | 2006-08-10 | — | — | US | disclosed |
| US-20050054856-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | EASTMAN CHEMICAL COMPANY (US) | 2005-03-10 | — | — | US | disclosed |
| US-6825356-B2 | REMAINING DONOR ATOMS OF THE LIGAND ARE SELECTED FROM THE GROUP CONSISTING OF C, N, P, AS, O, S, AND SE | EASTMAN CHEMICAL COMPANY | 2004-11-30 | — | — | US | disclosed |
| EP-1192189-B1 | CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS | EASTMAN CHEM CO (US) | 2004-09-29 | — | — | EP | disclosed |
| US-20030225228-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | EASTMAN CHEMICAL COMPANY | 2003-12-04 | — | — | US | disclosed |
| US-20030195110-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | E. I. DU PONT DE NEMOURS AND COMPANY | 2003-10-16 | — | — | US | disclosed |
| US-6559091-B1 | Metal complex ligated by a monodentate, bidentate, tridentate, or tetradentate ligand, wherein at least one of the donor atoms of the ligand is a nitrogen atom substituted by a 1-pyrrolyl or substituted 1- pyrrolyl group | EASTMAN CHEMICAL COMPANY | 2003-05-06 | — | — | US | disclosed |
| US-6545108-B1 | Ti, Zr, Hf, Cr, Mo, W, V, Nb, or Ta complex of a monodentate dianionic ligand in which a nitrogen atom is substituted by a 1-pyrrolyl and the remaining donor atoms are N, P, As, O, S, or Se | EASTMAN CHEMICAL COMPANY | 2003-04-08 | — | — | US | disclosed |
| EP-1192189-A2 | CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS | EASTMAN CHEMICAL COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000050470-A2 | CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS | EASTMAN CHEMICAL COMPANY (US) | 2000-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178490-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | NCL, NSFL1C, NCLN | KIF11 3906/4885JAK2 4434/4885TSHR 4856/4885 |
| US-20050054856-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | NCL, NSFL1C, NCLN | KIF11 3906/4885JAK2 4434/4885TSHR 4856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.